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浏览/检索结果: 共3条，第1-3条 帮助 限定条件 专题：北京大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity 期刊论文 CELL CHEMICAL BIOLOGY, 2017 Wang, Qian; Liberti, Maria V.; Liu, Pei; Deng, Xiaobing; Liu, Ying; Locasale, Jason W.; Lai, Luhua 收藏  |  浏览/下载：1/0  |  提交时间：2017/12/03 PHOSPHOGLYCERATE DEHYDROGENASE  CANCER METABOLISM  SYNTHESIS PATHWAY  ACCURATE DOCKING  BINDING-SITES  DRUG DESIGN  BIOSYNTHESIS  DISCOVERY  CELLS  COMBINATION   Modulating the Substrate Specificity of LTA4H Aminopeptidase by Using Chemical Compounds and Small-Molecule-Guided Mutagenesis 期刊论文 chembiochem, 2010 Jiang, Xiaolu; Zhou, Lu; Wu, Yiran; Wei, Dengguo; Sun, Chunyi; Jia, Jia; Liu, Ying; Lai, Luhua 收藏  |  浏览/下载：4/0  |  提交时间：2015/11/13 aminopeptidase activity  hydrolases  protein engineering  selectivity  small molecules  LEUKOTRIENE A(4) HYDROLASE  BIFUNCTIONAL ENZYME  ACTIVE-SITE  BIOLOGY  INFLAMMATION  CHEMISTRY  MECHANISM   Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules 期刊论文 journal of biological chemistry, 2009 Yang, Hongbo; Xiang, Jing; Wang, Nengdong; Zhao, Yun; Hyman, Joel; Li, Song; Jiang, Jin; Chen, James K.; Yang, Zhen; Lin, Shuo 收藏  |  浏览/下载：2/0  |  提交时间：2015/11/13 HEDGEHOG SIGNALING PATHWAY  BASAL-CELL CARCINOMA  SONIC HEDGEHOG  HUMAN HOMOLOG  BRAIN-TUMORS  FLOOR PLATE  MEDULLOBLASTOMA  INHIBITION  PROLIFERATION  CYCLOPAMINE