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西北高原生物研究所 [9]
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期刊论文 [72]
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Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury
期刊论文
MEDICINE, 2019, 卷号: 98, 期号: 31, 页码: 11
作者:
Ma, Zhenhua
;
Wang, Xiaomei
;
Yin, Peiyuan
;
Wu, Ruihong
;
Zhou, Lina
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/12/02
bile acid
biomarkers
drug induced liver injury
serum metabolic profiling
UHPLC-MS/MS
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Overcoming Poor Tabletability of Bulky Absorption Enhancers by Spray Drying Technology
期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 108, 期号: 6, 页码: 2128-2135
作者:
Fan, Weiwei
;
Wang, Aohua
;
Wu, Yue
;
Water, Jorrit J.
;
Buckley, Stephen T.
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
absorption enhancers
spray drying
compaction
physicochemical properties
amorphism
tableting
Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 126, 页码: 662-672
作者:
Zhang, Enhui
;
Xing, Ronge
;
Liu, Song
;
Li, Kecheng
;
Qin, Yukun
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/05/15
Targeted drug delivery
Chitosan
Docetaxel
Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 13
作者:
Lin, Hong
;
An, Yanpeng
;
Tang, Huiru
;
Wang, Yulan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/05
bile acids
high fat diet
deoxycholic acid
obesity
gut microbiota
UPLC-MS
Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.
期刊论文
Acta pharmaceutica Sinica. B, 2019, 卷号: No.1, 页码: 157-166
作者:
Yiqiao Gao
;
Wei Li
;
Jiaqing Chen
;
Xu Wang
;
Yingtong Lv
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/12/17
AUC-ROC,
area
under
receiver
operating
characteristic
BHB,
β-hydroxybutyric
acid
Biomarkers
C,
control
group
CA,
cholic
acid
CPT-11,
irinotecan
Complicating
toxicity
DBIL,
direct
bilirubin
DCA,
deoxycholic
acid
Diarrhea
FDR,
false
discovery
rate
GCA,
glycocholic
acid
Gastrointestinal
toxicity
IBIL,
indirect
bilirubin
IT-TOF/MS,
ion
trap/time-offlight
hybrid
mass
spectrometry
Individual
differences
Irinotecan
Lys,
lysine
MSTFA,
N-methyl-N-trifluoroacetamide
Metabolomics
NS,
non-sensitive
group
NSgt,
non-sensitive
for
gastrointestinal
toxicity
NSmt,
non-sensitive
for
myelosuppression
toxicity
OPLS-DA,
orthogonal
partial
least-squares-discriminant
analysis
PCA,
principal
component
analysis
PLS-DA,
partial
least-squares-discriminant
analysis
Phe,
phenylalanine
Prediction
QC,
quality
control
RSD,
relative
standard
deviation
S,
sensitive
group
Sgt,
sensitive
for
gastrointestinal
toxicity
Smt,
sensitive
for
myelosuppression
toxicity
T,
CPT-11
treated
group
Trp,
tryptophan
UFLC,
ultrafast
liquid
chromatography
VIP,
variable
importance
in
the
projection
pFDR,
false-discovery-rate-adjusted
P
value
magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 004, 页码: 507
作者:
Jing Zhao
;
Qingli Zhang
;
Jianhua Shen
;
Kai Wang
;
Jia Liu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
magnesium
lithospermate
B
diabetic
nephropathy
intestinal
microbiota
bile
acid
Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp
期刊论文
FRONTIERS IN MICROBIOLOGY, 2018, 卷号: 9, 期号: 1, 页码: 13
作者:
Xiong, Fan
;
Wu, Shan-Gong
;
Zhang, Jing
;
Jakovlic, Ivan
;
Li, Wen-Xiang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/07/02
bile acid
gut microbiota
lipid metabolism
freshwater fish
in vivo
Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp
期刊论文
FRONTIERS IN MICROBIOLOGY, 2018, 卷号: 9, 页码: 13
作者:
Wang, Gui-Tang
;
Li, Ming
;
Zou, Hong
;
Li, Wen-Xiang
;
Jakovlic, Ivan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2018/12/29
bile acid
gut microbiota
lipid metabolism
freshwater fish
in vivo
Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Zhao, Jing
;
Zhang, Qing-Li
;
Shen, Jian-Hua
;
Wang, Kai
;
Liu, Jia
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
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