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CORC

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Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen
收藏  |  浏览/下载：32/0  |  提交时间：2021/12/01
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong
收藏  |  浏览/下载：17/0  |  提交时间：2021/12/16
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing
收藏  |  浏览/下载：85/0  |  提交时间：2021/08/17
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong;  Song, Pinrao
收藏  |  浏览/下载：133/0  |  提交时间：2021/05/24
Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 11
作者:  Qiu, Xiaqiu;  Li, Yuanqing;  Yu, Bin;  Ren, Jie;  Huang, Huidan
收藏  |  浏览/下载：20/0  |  提交时间：2021/05/24
CDK9  Antitumor  PROTAC  AML  Degrader  
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan
收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng;  Xu, Gaoya;  Qu, Bingxue
收藏  |  浏览/下载：22/0  |  提交时间：2020/12/21
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng;  Xu, Gaoya;  Qu, Bingxue
收藏  |  浏览/下载：23/0  |  提交时间：2020/12/21
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13
作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi
收藏  |  浏览/下载：82/0  |  提交时间：2020/12/24
Medulloblastoma: Molecular understanding, treatment evolution, and new developments 期刊论文
PHARMACOLOGY & THERAPEUTICS, 2020, 卷号: 210, 页码: 13
作者:  Liu, Xiaohua;  Ding, Chunyong;  Tan, Wenfu;  Zhang, Ao
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01

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