QQ客服 官方微博 反馈留言

浏览/检索结果: 共21条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Conformational polymorphs of isotretinoin and their impact on physicochemical and biological properties 期刊论文 INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 610, 页码: 10 作者:  Cheng, Yinxiang;  Rong, Xiaoyi;  Xia, Mengyuan;  Zhang, Zaiyong;  Wang, Jian-Rong 收藏  |  浏览/下载：73/0  |  提交时间：2022/01/04 Polymorph  Isotretinoin  Stability  Solubility  Bioavailability   Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo 收藏  |  浏览/下载：42/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：40/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation 期刊论文 JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251 作者:  Li, Heng;  Zhang, Xianglei;  Xiang, Caigui;  Feng, Chunlan;  Fan, Chen 收藏  |  浏览/下载：88/0  |  提交时间：2021/11/04 PDE4  Arctigenin  Psoriasis  Inflammation   Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella 期刊论文 RSC MEDICINAL CHEMISTRY, 2021, 页码: 12 作者:  Guan, Xiang-Na;  Zhang, Tao;  Yang, Teng;  Dong, Ze;  Yang, Song 收藏  |  浏览/下载：21/0  |  提交时间：2021/12/16 Structural insights into ligand recognition and activation of the melanocortin-4 receptor 期刊论文 CELL RESEARCH, 2021, 页码: 13 作者:  Zhang, Huibing;  Chen, Li-Nan;  Yang, Dehua;  Mao, Chunyou;  Shen, Qingya 收藏  |  浏览/下载：35/0  |  提交时间：2021/11/04 Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor 期刊论文 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 9 作者:  Wang, Yue;  Guo, Shimeng;  Zhuang, Youwen;  Yun, Ying;  Xu, Peiyu 收藏  |  浏览/下载：43/0  |  提交时间：2021/11/04 Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design 期刊论文 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 15 作者:  Lu, Shaoyong;  He, Xinheng;  Yang, Zhao;  Chai, Zongtao;  Zhou, Shuhua 收藏  |  浏览/下载：36/0  |  提交时间：2021/11/04 Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L. 期刊论文 CHEMISTRY & BIODIVERSITY, 2021, 页码: 6 作者:  Fan, Min;  Wang, Ting;  Peng, Li-Yan;  Huang, Jun-Shang;  Wu, Xing-De 收藏  |  浏览/下载：21/0  |  提交时间：2021/11/04 Salvia hispanica  neo-clerodane diterpenoid  salvihispin H  type 2 diabetes mellitus   Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 期刊论文 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 12 作者:  Zhang, Hui;  Chen, Kun;  Tan, Qiuxiang;  Shao, Qiang;  Han, Shuo 收藏  |  浏览/下载：48/0  |  提交时间：2021/08/17