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浏览/检索结果: 共53条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo 收藏  |  浏览/下载：42/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10 作者:  Zou, Hui-xi;  Zhang, Yu-feng;  Zhong, Da-fang;  Jiang, Yong;  Liu, Fei 收藏  |  浏览/下载：19/0  |  提交时间：2022/01/04 furmonertinib  autoinduction  food effect  alkaline phosphatase  body weight  pharmacokinetics  modeling and simulation  NSCLC   Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics 期刊论文 CHEMICAL COMMUNICATIONS, 2021, 卷号: 57, 期号: 91, 页码: 12098-12110 作者:  Tong, Pei-Hong;  Zhu, Ling;  Zang, Yi;  Li, Jia;  He, Xiao-Peng 收藏  |  浏览/下载：29/0  |  提交时间：2021/12/16 The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206 作者:  Jiang, Yuchen;  Peng, Xia;  Ji, Yinchun;  Dai, Yang;  Fang, Yanfen 收藏  |  浏览/下载：29/0  |  提交时间：2021/12/16 GADD45 beta stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation 期刊论文 PHARMACOLOGICAL RESEARCH, 2021, 卷号: 173, 页码: 11 作者:  Dong, Yunxia;  Ma, Ningning;  Fan, Lei;  Yuan, Luyang;  Wu, Qian 收藏  |  浏览/下载：60/0  |  提交时间：2021/12/16 Non-alcoholic fatty liver disease  GADD45 beta  HSP72  Lipid accumulation  Insulin resistance   Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen 收藏  |  浏览/下载：32/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14822-14847 作者:  Wei, Dan;  Wang, Hanlin;  Zeng, Qinghe;  Wang, Wenjing;  Hao, Bingbing 收藏  |  浏览/下载：30/0  |  提交时间：2021/12/16 TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery 期刊论文 DRUG DISCOVERY TODAY, 2021, 卷号: 26, 期号: 10, 页码: 2445-2455 作者:  Xiang, Shuang;  Song, Shukai;  Tang, Haotian;  Smaill, Jeff B.;  Wang, Aiqun 收藏  |  浏览/下载：23/0  |  提交时间：2021/12/01 Antibiotic resistance  Computational biology  Databases  In silico tools   Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ 期刊论文 FRONTIERS IN ENDOCRINOLOGY, 2021, 卷号: 12, 页码: 14 作者:  Yang, Xinyu;  Zhang, Xianfeng;  Yang, Wei;  Yu, Hang;  He, Qianyan 收藏  |  浏览/下载：49/0  |  提交时间：2021/11/04 gut microbiota  adipose tissue dysfunction  molecular endocrinology  cardiovascular disease(s)  gut dysbiosis