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科研机构
合肥物质科学研究院 [6]
上海药物研究所 [4]
内容类型
期刊论文 [10]
发表日期
2021 [10]
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发表日期:2021
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LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
A phase II study of tislelizumab plus chemotherapy in EGFR mutated advanced non-squamous NSCLC patients failed to EGFR TKI therapies: First analysis
期刊论文
ANNALS OF ONCOLOGY, 2021, 卷号: 32
作者:
Han, B.
;
Tian, P.
;
Zhao, Y.
;
Yu, X.
;
Guo, Q.
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/01/10
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
Liquid chromatography-mass spectrometry based metabolic characterization of pleural effusion in patients with acquired EGFR-TKI resistance
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 202
作者:
Li, Na
;
Mao, Weimin
;
Gao, Yun
;
Wang, Ding
;
Song, Zhengbo
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/08/31
Lung cancer
EGFR-TKI
Resistance
Pleural effusion
Metabolomics
Biomarker
D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156).
期刊论文
CANCER RESEARCH, 2021, 卷号: 81
作者:
Lu, Shun
;
Zhang, Yiping
;
Zhang, Guojun
;
Zhou, Jianying
;
Cang, Shundong
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/11/01
The correlation between the abundance of EGFR T790M mutation and osimertinib response in advanced non-small cell lung cancer
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2021, 卷号: 10
作者:
Pan, Guoqiang
;
Chen, Kaiyan
;
Yu, Xiaoqing
;
Sheng, Jiamin
;
Fan, Yun
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/01
Non-small cell lung cancer (NSCLC)
T790M abundance
droplet digital PCR (ddPCR)
next generation sequencing (NGS)
osimertinib
Third-generation EGFR inhibitor HS-10296 in combination with famitinib, a multi-targeted tyrosine kinase inhibitor, exerts synergistic antitumor effects through enhanced inhibition of downstream signaling in EGFR-mutant non-small cell lung cancer cells
期刊论文
THORACIC CANCER, 2021, 页码: 9
作者:
Zhang, Mi
;
Quan, Haitian
;
Fu, Li
;
Li, Yun
;
Fu, Haoyu
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
EGFR‐
mutant non‐
small cell lung cancer
famitinib
HS‐
10296
multi‐
targeted tyrosine kinase inhibitor
third‐
generation EGFR inhibitor
Adverse events associated with nilotinib in chronic myeloid leukemia: mechanisms and management strategies
期刊论文
EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2021
作者:
Wang, Zeng
;
Jiang, Liyu
;
Yan, Hao
;
Xu, Zhifei
;
Luo, Peihua
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/04/26
Adverse events
chronic myeloid leukemia
management
mechanisms
molecular target
nilotinib
Biomimetic codelivery overcomes osimertinib-resistant NSCLC and brain metastasis via macrophage-mediated innate immunity
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2021, 卷号: 329, 页码: 1249-1261
作者:
Zhao, Pengfei
;
Zhang, Jiaxin
;
Wu, Aihua
;
Zhang, Meng
;
Zhao, Yuge
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2021/05/24
Brain targeting delivery
Tumor-associated macrophage
Osimertinib resistance
Brain metastasis
Innate immunity
Combination therapy
A Case of Resistance to Selective RET-TKI Therapy With Pleural-Genotyped MET Amplification and Response to Crizotinib
期刊论文
CLINICAL LUNG CANCER, 2021, 卷号: 22
作者:
Chen, Kaiyan
;
Zhang, Fanrong
;
Pan, Guoqiang
;
Sheng, Jiamin
;
Ye, Junyi
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/03/15
Crizotinib
MET
Non-small-cell lung cancer
RET
Resistance
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