QQ客服 官方微博 反馈留言

浏览/检索结果: 共20条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Yu, Ming-cheng;  Yang, Feng;  Ding, Xiao-yu;  Sun, Nan-nan;  Jiang, Zheng-yuan 收藏  |  浏览/下载：84/0  |  提交时间：2020/12/24 RORγ  t  cocrystal structures  MD simulation  “  short”  inverse agonists  agonists  “  long”  inverse agonists   Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7 作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan 收藏  |  浏览/下载：20/0  |  提交时间：2021/05/24 Drug design  CBP  Bromodomain  Inhibitor  Acute myeloid leukemia   Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5 作者:  Zhang, Bin;  Liao, Liping;  Wu, Fan;  Zhang, Fengcai;  Sun, Zhongya 收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24 SMYD2 inhibitors  Thermal shift assay  Structure-activity relationships   A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines 期刊论文 ORGANIC CHEMISTRY FRONTIERS, 2020, 卷号: 7, 期号: 20, 页码: 3186-3192 作者:  Cheng, Yilang;  Han, Xu;  Li, Junyou;  Zhou, Yu;  Liu, Hong 收藏  |  浏览/下载：6/0  |  提交时间：2020/12/24 Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities 期刊论文 CHEMISTRY & BIODIVERSITY, 2020, 页码: 10 作者:  Hu, Yu-Hong;  Liu, Jin;  Li, Heng;  Tang, Wei;  Li, Xu-Wen 收藏  |  浏览/下载：36/0  |  提交时间：2020/12/21 Citrus changshan-huyou  limonoids  structure modification  anti-inflammation   The impact of structural modification of sulfated polysaccharides on bone morphogenic protein 2 and inhibition of endothelial cell angiogenesis 期刊论文 CARBOHYDRATE RESEARCH, 2020, 卷号: 496, 页码: 10 作者:  Wang, Ying;  Xiao, Fei;  Jin, Can;  Wang, Wucheng;  Chen, Xia 收藏  |  浏览/下载：17/0  |  提交时间：2020/12/21 Sulfated polysaccharides  Bone morphogenic protein 2  Structure and activity relationship  Angiogenesis   Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery 期刊论文 BIOMATERIALS, 2020, 卷号: 255, 页码: 12 作者:  Chen, Binfan;  Gao, Ang;  Tu, Bin;  Wang, Yonghui;  Yu, Xiaolu 收藏  |  浏览/下载：29/0  |  提交时间：2020/12/24 Tumor-associated macrophage  Glycolysis  mTOR  Angiogenesis  Tumor immune microenvironment  Liposome   The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties 期刊论文 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 卷号: 5, 期号: 1, 页码: 14 作者:  Liu, Na;  Yang, Rui;  Shi, Ying;  Chen, Ling;  Liu, Yating 收藏  |  浏览/下载：32/0  |  提交时间：2020/12/21 Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 页码: 6 作者:  Shi, Wei;  Tang, Feng;  Ao, Jiwei;  Yu, Qun;  Liu, Junjie 收藏  |  浏览/下载：17/0  |  提交时间：2020/12/21 acylation  click chemistry  peptides  rearrangements  silver   Synthesis and Cytotoxic Activity of Novel C-23-Modified Asiatic Acid Derivatives 期刊论文 MOLECULES, 2020, 卷号: 25, 期号: 16, 页码: 20 作者:  Lu, Yi-hong;  Chen, Ming-cang;  Liu, Fang;  Xu, Zhou;  Tian, Xiao-ting 收藏  |  浏览/下载：13/0  |  提交时间：2020/12/24 asiatic acid  modification at C-23  intramolecular hydrogen bonding  cytotoxic activity