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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors 期刊论文 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16 作者:  Darbalaei, Sanaz;  Yuliantie, Elita;  Dai, Antao;  Chang, Rulue;  Zhao, Peishen 收藏  |  浏览/下载：19/0  |  提交时间：2020/12/21 G protein-coupled receptor  Glucagon-like peptide-1 receptor  Glucagon receptor  Biased agonism  Unimolecular dual agonist   Synthesis and Cytotoxic Activity of Novel C-23-Modified Asiatic Acid Derivatives 期刊论文 MOLECULES, 2020, 卷号: 25, 期号: 16, 页码: 20 作者:  Lu, Yi-hong;  Chen, Ming-cang;  Liu, Fang;  Xu, Zhou;  Tian, Xiao-ting 收藏  |  浏览/下载：13/0  |  提交时间：2020/12/24 asiatic acid  modification at C-23  intramolecular hydrogen bonding  cytotoxic activity   Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5 作者:  Satheeshkumar, Rajendran;  Zhu, Rui;  Feng, Bo;  Huang, Chao;  Gao, Ya 收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01 Heterocyclic bis-aryl amides  PTP1B  SHP2  Inhibitors  Structure-activity relationships (SAR)   Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase 期刊论文 NUCLEIC ACIDS RESEARCH, 2020, 卷号: 48, 期号: 5, 页码: 2709-2722 作者:  Nguyen, Phuong D. M.;  Zheng, Jie;  Gremminger, Thomas J.;  Qiu, Liming;  Zhang, Dong 收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 Synthesis of triazolotriazine derivatives as c-Met inhibitors 期刊论文 MOLECULAR DIVERSITY, 2020, 页码: 8 作者:  Guo, Yuting;  Peng, Xia;  Ji, Yinchun;  Zhang, Yitong;  Ding, Jian 收藏  |  浏览/下载：37/0  |  提交时间：2020/12/24 Receptor tyrosine kinase  c-Met  Triazolotriazine  SAR  Cellular potency   Synthesis and Structure-Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori 期刊论文 MOLECULES, 2020, 卷号: 25, 期号: 6, 页码: 12 作者:  Fan, Tianyun;  Guo, Xixi;  Zeng, Qingxuan;  Wei, Wei;  You, Xuefu 收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 Helicobacter pylori  palmatine  synthesis  structure-activity relationship  urease   Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422 作者:  Lai, Meng-zhen;  Song, Pei-ran;  Dou, Dou;  Diao, Yan-yan;  Tong, Lin-jiang 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 B cell receptor  Bruton's tyrosine kinase  ibrutinib  small-molecule inhibitor  B cell malignancies   Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 423-431 作者:  Guo, Wei;  Yao, Sheng;  Sun, Pu;  Yang, Tian-biao;  Tang, Chun-ping 收藏  |  浏览/下载：79/0  |  提交时间：2020/07/01 indoleamine 2  3-dioxygenase 1 inhibitor  natural product library  high-throughput fluorescence-based screening   Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 4, 页码: 4 作者:  Xiong, Juan;  Hu, Chang-Ling;  Wang, Pei-Pei;  Gao, Ding-Ding;  Huang, Fang 收藏  |  浏览/下载：45/0  |  提交时间：2020/07/01 Glyptostrobus pensilis  Cupressaceae  Endangered conifer  Spirobiflavonoids  PTP1B inhibition   Bioactivity Prediction Based on Matched Molecular Pair and Matched Molecular Series Methods 期刊论文 CURRENT PHARMACEUTICAL DESIGN, 2020, 卷号: 26, 期号: 33, 页码: 4195-4205 作者:  Ding, Xiaoyu;  Cui, Chen;  Wang, Dingyan;  Zhao, Jihui;  Zheng, Mingyue 收藏  |  浏览/下载：14/0  |  提交时间：2020/12/21 Matched molecular pair  matched molecular series  bioactivity prediction  SAR transfer  application domain  lead optimization