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上海药物研究所 [25]
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昆明植物研究所 [3]
湖南大学 [3]
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期刊论文 [58]
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2019 [58]
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Pharmacolo... [1]
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Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23
作者:
Zou, Yi
;
Hu, Yue
;
Ge, Shushan
;
Zheng, Yingbo
;
Li, Yuezhen
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
IDO1
Heme
T cell
Cancer immunotherapy
Virtual screening
Drug design
Molecular dynamics simulation
Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer
期刊论文
PHYTOMEDICINE, 2019, 卷号: 65, 页码: 11
作者:
Wang Yuwei
;
Tang Chunping
;
Yao Sheng
;
Lai Huanling
;
Li Runze
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer
Natural product
Croton tiglium
Protein kinase C
Molecular modelling
Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 171-190
作者:
Liu, Ruiqi
;
Zhang, Zhuqing
;
Yang, Hong
;
Zhou, Kaixin
;
Geng, Meiyu
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
p300 inhibitors
Epigenetics
Structure-activity relationship
Sensitive tumor cell proliferation
C646
DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 17, 期号: 5, 页码: 478-495
作者:
Wan, Fangping
;
Zhu, Yue
;
Hu, Hailin
;
Dai, Antao
;
Cai, Xiaoqing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Deep learning
Machine learning
Drug discovery
In silico drug screening
Compound-protein interaction prediction
Binding and activity of sulfated metabolites of lower-chlorinated polychlorinated biphenyls towards thyroid hormone receptor alpha
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 180, 页码: 686-692
作者:
Ren, Xiao-Min
;
Li, Chuan-Hai
;
Zhang, Jian-Qing
;
Guo, Liang-Hong
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  |  
浏览/下载:3/0
  |  
提交时间:2020/09/10
Lower-chlorinated polychlorinated biphenyls
LC-PCB sulfates
TR
Agonistic activity
TH system disruption effect
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 11
作者:
Jones, Alexander X.
;
Cao, Yong
;
Tangi, Yu-Liang
;
Wang, Jian-Hua
;
Ding, Yue-He
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2019/12/10
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 11
作者:
Jones, Alexander X.
;
Cao, Yong
;
Tangi, Yu-Liang
;
Wang, Jian-Hua
;
Ding, Yue-He
收藏
  |  
浏览/下载:101/0
  |  
提交时间:2019/12/02
New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells
期刊论文
ARCHIVES OF TOXICOLOGY, 2019, 卷号: 93, 期号: 9, 页码: 2661-2671
作者:
Gu, Yu-Xin
;
Liang, Xiao-Xing
;
Yin, Nuo-Ya
;
Yang, Yu
;
Wan, Bin
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  |  
浏览/下载:18/0
  |  
提交时间:2020/09/10
Bisphenol analogues
O-GlcNAcase
Inhibition
Neurotoxicity
Discovery of betulinaldehyde as a natural ROR gamma t agonist
期刊论文
FITOTERAPIA, 2019, 卷号: 137, 页码: 8
作者:
Yang, Feng
;
Zhang, Ruihan
;
Ni, Dongxuan
;
Luo, Xiaomin
;
Chen, Shijie
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
ROR gamma t
Receptor agonist
Triterpenoids
Alpha screen
Molecular docking
Structural and functional studies of USP20 ZnF-UBP domain by NMR
期刊论文
PROTEIN SCIENCE, 2019, 卷号: 28, 期号: 9, 页码: 1606-1619
作者:
Yang, Yuanyuan
;
Ding, Yiluan
;
Zhou, Chen
;
Wen, Yi
;
Zhang, Naixia
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
deubiquitinase
NMR
solution structure
USP20
ZnF-UBP domain
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