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期刊论文 [193]
会议论文 [1]
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2019 [194]
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发表日期:2019
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Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
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  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway
期刊论文
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 卷号: 2019, 页码: 15
作者:
Liu, Yunen
;
Tong, Changci
;
Xu, Ying
;
Gong, Peifang
;
Liu, Ying
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  |  
浏览/下载:38/0
  |  
提交时间:2021/02/02
In vitro evaluation of the neuroprotective effect of oligo-porphyran from Porphyra yezoensis in PC12 cells
期刊论文
JOURNAL OF APPLIED PHYCOLOGY, 2019, 卷号: 31, 期号: 4, 页码: 2559-2571
作者:
Liu, YingJuan
;
Deng, Zhenzhen
;
Geng, Lihua
;
Wang, Jing
;
Zhang, Quanbin
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  |  
浏览/下载:113/0
  |  
提交时间:2019/11/14
Rhodophyta
Oligo-porphyran
Apoptosis
6-OHDA
PC12 cells
Mitochondria
Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 8, 页码: 1010-1018
作者:
Liu, Ying-luo
;
Zhou, Xiao-yu
;
Xuan, Li-jiang
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  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
traditional Chinese medicine
Salvia miltiorrhiza
magnesium lithospermate B
microcirculation dysfunction
NO
endothelium nitric oxide synthase
PI3K/AKT pathway
lncRNA H19 binds VGF and promotes pNEN progression via PI3K/AKT/CREB signaling
期刊论文
ENDOCRINE-RELATED CANCER, 2019, 卷号: 26, 期号: 7, 页码: 643-658
作者:
Ji, Meng
;
Yao, Yanli
;
Liu, Anan
;
Shi, Ligang
;
Chen, Danlei
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  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
H19
VGF
long non-coding RNA
pancreatic neuroendocrine neoplasm
PI3K/AKT/CREB
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
作者:
Guo, Chuanlong
;
Wang, Lijun
;
Zhao, Yue
;
Jiang, Bo
;
Luo, Jiao
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  |  
浏览/下载:118/0
  |  
提交时间:2019/08/28
bromophenol
apoptosis
autophagy
phosphoinositide 3-kinase
protein kinase B
mechanistic target of rapamycin signaling
reactive oxygen species
Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway
期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 4, 页码: 11
作者:
Xu, Kuo
;
Guo, Chuanlong
;
Meng, Jie
;
Tian, Haiying
;
Guo, Shuju
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/08/28
Aspergillus
naphthopyrones
cytotoxicity
endophytic fungus
Leathesia nana
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
期刊论文
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214
作者:
Du, Te
;
Yang, Liu
;
Xu, Xu
;
Shi, Xiaofan
;
Xu, Xin
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
vincamine
GPR40
beta-cell function
insulin secretion
type 2 diabetes
Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway
期刊论文
Acta pharmacologica Sinica, 2019
作者:
Gao, Fei
;
Li, Jiao-Meng
;
Xi, Cong
;
Li, Hui-Hui
;
Liu, Ying-Luo
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  |  
浏览/下载:107/0
  |  
提交时间:2019/03/13
Nrf2
Pi3k/akt
Pkc
Endothelium
Human Dermal Microvascular Endothelial Cells
Inflammation
Lipopolysaccharide
Magnesium Lithospermate b
Rat Superior Mesenteric Artery Rings
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