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科研机构
上海药物研究所 [27]
内容类型
期刊论文 [27]
发表日期
2019 [27]
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浏览/检索结果:
共27条,第1-10条
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发表日期:2019
专题:上海药物研究所
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Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23
作者:
Zou, Yi
;
Hu, Yue
;
Ge, Shushan
;
Zheng, Yingbo
;
Li, Yuezhen
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
IDO1
Heme
T cell
Cancer immunotherapy
Virtual screening
Drug design
Molecular dynamics simulation
Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 21, 页码: 9983-9989
作者:
Zhou, Fang
;
Ding, Kang
;
Zhou, Yiqing
;
Liu, Yang
;
Liu, Xiaoyan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Synthesis of Arylstannanes via Palladium-Catalyzed Decarbonylative Coupling of Aroyl Fluorides
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2019, 页码: 7
作者:
Kayumov, Muzaffar
;
Zhao, Jian-Nan
;
Mirzaakhmedov, Sharafitdin
;
Wang, Dong-Yu
;
Zhang, Ao
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
stannylation
Pd-catalyzed
acyl fluorides
decarbonylation
late-stage diversification
TRAIL-based gene delivery and therapeutic strategies
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1373-1385
作者:
Zhong, Hui-hai
;
Wang, Hui-yuan
;
Li, Jian
;
Huang, Yong-zhuo
收藏
  |  
浏览/下载:115/0
  |  
提交时间:2020/07/01
TRAIL
gene delivery
gene therapy
DNA
drug delivery systems
non-viral vectors
cancer therapy
Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11
作者:
Gao, Yuxiong
;
Zhang, Dan
;
Yang, Changyong
;
Duan, Xiaotao
;
Li, Xiuli
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Anti-CD47 monoclonal antibody
LC-MS
Adsorption issue
Electrochemiluminescence
Pharmacokinetics
Cross-validation
Designing of novel ERR gamma inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2019, 卷号: 28, 期号: 10, 页码: 1661-1673
作者:
Li, Rui
;
Du, Yongli
;
Shen, Jingkang
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
ERR gamma inverse agonist
Molecular docking
3D-QSAR
CoMFA
CoMSIA
Exploring the Ligand Binding/Unbinding Pathway by Selectively Enhanced Sampling of Ligand in a Protein-Ligand Complex
期刊论文
JOURNAL OF PHYSICAL CHEMISTRY B, 2019, 卷号: 123, 期号: 38, 页码: 7974-7983
作者:
Shao, Qiang
;
Zhu, Weiliang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
Rhodium-Catalyzed Enantioselective Addition of Arylboroxines to Isatin-Derived N-Boc Ketimines Using Chiral Phosphite-Olefin Ligands: Asymmetric Synthesis of 3-Aryl-3-amino-2-oxindoles
期刊论文
ORGANIC LETTERS, 2019, 卷号: 21, 期号: 18, 页码: 7493-7497
作者:
Yu, Yue-Na
;
Qi, Wei-Yi
;
Wu, Chun-Yan
;
Xu, Ming-Hua
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
Ligand-induced activation of ERK1/2 signaling by constitutively active G(s)-coupled 5-HT receptors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1157-1167
作者:
Liu, Ping
;
Yin, Yu-ling
;
Wang, Ting
;
Hou, Li
;
Wang, Xiao-xi
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
5-HT4R
5-HT6R
5-HT7AR
5-HT
ERK1/2
G(s)
beta-arrestin
Fyn
Src
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