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浏览/检索结果: 共39条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 RepSox, a small molecule inhibitor of the TGF beta receptor, induces brown adipogenesis and browning of white adipocytes 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1523-1531 作者:  Tu, Wan-zhi;  Fu, Yan-bin;  Xie, Xin 收藏  |  浏览/下载：42/0  |  提交时间：2020/07/01 RepSox  brown adipogenesis  TGF-beta receptor  TGF-beta inhibitor  adipocyte  differentiation   Targeting epigenetic machinery: Emerging novel allosteric inhibitors 期刊论文 PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24 作者:  Ye, Fei;  Huang, Jing;  Wang, Hongbo;  Luo, Cheng;  Zhao, Kehao 收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 Epigenetics  PRC2  MLL complex  SWI/SNF  DNMT1  allosteric inhibitors   Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 21 作者:  Chen, Deheng;  Lu, Tian;  Yan, Ziqin;  Lu, Wenchao;  Lyu, Xilin 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 Bromodomain  BET protein  BD2  Selective  Crystal structure   Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1386-1393 作者:  Cui, Xue;  Guo, Yu-e;  Fang, Jia-hui;  Shi, Chang-jie;  Suo, Na 收藏  |  浏览/下载：68/0  |  提交时间：2020/07/01 donepezil  aricept  oligodendrocyte  oligodendrocyte progenitor cell  differentiation  myelin sheaths  remyelination  CNS demyelinating disorders  multiple sclerosis   PD-L1 expression levels on tumor cells affect their immunosuppressive activity 期刊论文 ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 5, 页码: 5399-5407 作者:  Zheng, Yang;  Fang, You-Chen;  Li, Jing 收藏  |  浏览/下载：53/0  |  提交时间：2020/07/01 programmed cell death 1  programmed death-ligand 1  co-culture  immunosuppression  signaling pathway   Dynamic modifications of biomacromolecules: mechanism and chemical interventions 期刊论文 SCIENCE CHINA-LIFE SCIENCES, 2019, 卷号: 62, 期号: 11, 页码: 1459-1471 作者:  Wang, Chu;  Zou, Peng;  Yang, Caiguang;  Liu, Lei;  Cheng, Liang 收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01 chemical biology  biomacromolecule  dynamic modification  modification analysis  chemical intervention   Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 179, 页码: 38-55 作者:  Chen, Shulun;  Guo, Wei;  Liu, Xiaohua;  Sun, Pu;  Wang, Yi 收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 Indoleamine 2,3-dioxygenase  Immunotherapy  Oxadiazole  PD-1  Life span   NLG919/cyclodextrin complexation and anti-cancer therapeutic benefit as a potential immunotherapy in combination with paclitaxel 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 138, 页码: 8 作者:  Xu, Jian;  Ren, Xiaohong;  Guo, Tao;  Sun, Xian;  Chen, Xiaojin 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 Cyclodextrins  NLG919  Solubility enhancement  Paclitaxel  IDO-1 combination immunochemotherapy   DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening 期刊论文 GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 17, 期号: 5, 页码: 478-495 作者:  Wan, Fangping;  Zhu, Yue;  Hu, Hailin;  Dai, Antao;  Cai, Xiaoqing 收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 Deep learning  Machine learning  Drug discovery  In silico drug screening  Compound-protein interaction prediction   New linker structures applied in glycosite-specific antibody drug conjugates 期刊论文 ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 17, 页码: 3144-3149 作者:  Faridoon;  Shi, Wei;  Qin, Ken;  Tang, Yubo;  Li, Mingjie 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01