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浏览/检索结果: 共31条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells 期刊论文 CHEM, 2019, 卷号: 5, 期号: 11, 页码: 2955-2968 作者:  Hu, Wei;  Yuan, Yi;  Wang, Cai-Hu;  Tian, Hong-Tao;  Guo, An-Di 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 USP9X stabilizes BRCA1 and confers resistance to DNA-damaging agents in human cancer cells 期刊论文 CANCER MEDICINE, 2019, 卷号: 8, 期号: 15, 页码: 6730-6740 作者:  Lu, Qin;  Zhang, Fang-Lin;  Lu, Da-Yun;  Shao, Zhi-Ming;  Li, Da-Qiang 收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 BRCA1  breast cancer  deubiquitinase  PARP inhibitor  USP9X   Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 43, 页码: 21732-21738 作者:  Liu, Bin;  Zhang, Zhijian;  Hu, Yanyun;  Lu, Yan;  Li, Duanzhuo 收藏  |  浏览/下载：59/0  |  提交时间：2020/07/01 type 2 diabetes  gluconeogenesis  hepatic glucose production  ER stress  USP14   Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1364-1372 作者:  Shi, Yi;  Wang, Ting;  Zhou, X. Edward;  Liu, Qiu-Feng;  Jiang, Yi 收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01 uricase  thermostability  disulfide cross-linking  crystal structure   Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 10, 页码: 4303-4318 作者:  Chen, Jianzhong;  Wang, Jinan;  Yin, Baohua;  Pang, Laixue;  Wang, Wei 收藏  |  浏览/下载：114/0  |  提交时间：2020/07/01 beta-amyloid cleaving enzyme  binding selectivity  MSMD  hierarchical clustering analysis  MM-GBSA   Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity 期刊论文 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 39, 期号: 9, 页码: 2599-2608 作者:  Li Yingjun;  Zhao Yue;  Jin Kun;  Gao Lixin;  Sheng Li 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 1,3,4-thiadiazolamide  carbazole  benzimidazole  synthesis  PTP1B inhibitor  molecular docking  density functional theory (DFT) study   Pharmacological characterization of TQ05310, a potent inhibitor of isocitrate dehydrogenase 2 R140Q and R172K mutants 期刊论文 CANCER SCIENCE, 2019, 页码: 9 作者:  Gao, Mingzhao;  Zhu, Hongmei;  Fu, Li;  Li, Yun;  Bao, Xubin 收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01 AG-221  IDH2  leukemia  R140Q  R172K   Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans 期刊论文 DRUG METABOLISM AND DISPOSITION, 2019, 卷号: 47, 期号: 8, 页码: 843-853 作者:  Li, Xiuli;  Sun, Jingchao;  Guo, Zitao;  Zhong, Dafang;  Chen, Xiaoyan 收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine 期刊论文 CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 13 作者:  Tian, Chang-Qing;  Chen, Lin;  Chen, Hua-Dong;  Huan, Xia-Juan;  Hu, Jian-Ping 收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis 期刊论文 NATURE, 2019, 卷号: 571, 期号: 7763, 页码: 127-+ 作者:  Wang, Xiongjun;  Liu, Ruilong;  Zhu, Wencheng;  Chu, Huiying;  Yu, Hua 收藏  |  浏览/下载：17/0  |  提交时间：2020/07/01