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上海药物研究所 [46]
山东大学 [13]
复旦大学上海医学院 [10]
四川大学 [8]
武汉大学 [5]
湖南大学 [5]
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期刊论文 [121]
发表日期
2018 [121]
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Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
期刊论文
European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689
作者:
Wang, Qi
;
Dai, Yang
;
Ji, Yinchun
;
Shi, Huanyu
;
Guo, Zuhao
收藏
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浏览/下载:85/0
  |  
提交时间:2019/01/08
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
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浏览/下载:14/0
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提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791
作者:
Guo, Bin
;
Guo, Shimeng
;
Huang, Jing
;
Li, Jingya
;
Li, Jia
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浏览/下载:43/0
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提交时间:2019/01/08
GPR40 agonist
2,3-Dihydrobenzo[b][1,4]dioxine
Insulin secretion
Type 2 diabetes mellitus
Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection
期刊论文
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2018, 卷号: 138, 期号: 4, 页码: 247-256
作者:
Yao, Xingang
;
Guo, Songxin
;
Wu, Wenyu
;
Wang, Jinan
;
Wu, Shengen
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浏览/下载:100/0
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提交时间:2019/01/08
RdRp inhibitor
Quinazolinone derivative
DENV2 infection
Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 6, 页码: 1998-2008
作者:
Zhong, Li
;
Liu, Qing
;
Ting, Yan Sie
;
Vun Yien Thien
;
Kalong, Nurwafa Syafiqah Binti
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  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
adenine derivative
structural optimization
thioredoxin-binding protein-2
thioredoxin-interacting protein
vitamin D3-upregulated protein-1
Structure-Based Design of 1-Heteroary1-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 21, 页码: 9621-9636
作者:
Peng, Panfeng
;
Chen, Huan
;
Zhu, Ya
;
Wang, Zhilong
;
Li, Jian
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浏览/下载:56/0
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提交时间:2019/01/08
Discovery of JND3229 as a New EGFR(C797S) Mutant Inhibitor with In Vivo Monodrug Efficacy
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 9, 期号: 11, 页码: 1123-1127
作者:
Lu, Xiaoyun
;
Zhang, Tao
;
Zhu, Su-Jie
;
Xun, Qiuju
;
Tong, Lingjiang
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浏览/下载:108/0
  |  
提交时间:2019/01/08
EGFR(C797s)
Clinical resistance
Fourth-generation nhibitors
Monodrug efficacy
Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9177-9204
作者:
Li, Daqiang
;
Zhang, Xiaotuan
;
Ma, Xiaodong
;
Xu, Lei
;
Yu, Jianjun
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浏览/下载:30/0
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提交时间:2019/01/08
Characterization of Solid-State Drug Polymorphs and Real-Time Evaluation of Crystallization Process Consistency by Near-Infrared Spectroscopy
期刊论文
FRONTIERS IN CHEMISTRY, 2018, 卷号: 6, 页码: 7
作者:
Qi, Shu-Ye
;
Tian, Ye
;
Zou, Wen-Bo
;
Hu, Chang-Qin
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浏览/下载:51/0
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提交时间:2018/12/04
Process Consistency
Drug Polymorph
Solid-state Nuclear Magnetic Resonance Spectroscopy
Near-infrared Spectroscopy
Raman Microscopy
Application of ITC-Based Characterization of Thermodynamic and Kinetic Association of Ligands With Proteins in Drug Design
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Su, Haixia
;
Xu, Yechun
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浏览/下载:16/0
  |  
提交时间:2019/01/08
ITC
thermodynamics
kinetics
protein-ligand recognition
drug design
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