QQ客服 官方微博 反馈留言

浏览/检索结果: 共6条，第1-6条 帮助 限定条件 发表日期：2018     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Application of ITC-Based Characterization of Thermodynamic and Kinetic Association of Ligands With Proteins in Drug Design 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Su, Haixia;  Xu, Yechun 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 ITC  thermodynamics  kinetics  protein-ligand recognition  drug design   Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5) 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636 作者:  Ni, Wei;  Wang, Huan;  Li, Xiaokang;  Zheng, Xinyu;  Wang, Manjiong 收藏  |  浏览/下载：44/0  |  提交时间：2019/01/08 Multifunctional agents  AChE inhibitors  PDE5 inhibitors  Alzheimer's disease   Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345 作者:  Mao, Fei;  Wang, Huan;  Ni, Wei;  Zheng, Xinyu;  Wang, Manjiong 收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08 Alzheimer's disease  drug repositioning  dual-target inhibitor  AChE inhibition  PDE5 inhibition   Design and synthesis of furyl/thineyl pyrroloquinolones based on natural alkaloid perlolyrine, lead to the discovery of potent and selective PDE5 inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 页码: 30-38 作者:  Zheng, Hongbo;  Li, Lin;  Sun, Bin;  Gao, Yun;  Song, Wei 收藏  |  浏览/下载：113/0  |  提交时间：2019/12/11 PDE5 inhibitors  Pyrroloquinolones  Bioavailability  Male erectile  dysfunction (MED)   Discovery of furyl/thienyl beta-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 767-780 作者:  Zheng, Hongbo;  Wu, Yifeng;  Sun, Bin;  Cheng, Chuanle;  Qiao, Yanan 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/11 beta-Carboline derivatives  PDE5 inhibitors  Vasorelaxant effect  Structure-activity relationship   Discovery of furyl/thienyl β-carboline derivatives as potent and selective PDE5 inhibitors with excellent vasorelaxant effect 期刊论文 European Journal of Medicinal Chemistry, 2018, 卷号: 158, 页码: 767-780 作者:  Zheng H.;  Wu Y.;  Sun B.;  Cheng C.;  Qiao Y. 收藏  |  浏览/下载：11/0  |  提交时间：2019/12/11 PDE5 inhibitors  Structure-activity relationship  Vasorelaxant effect  β-Carboline derivatives