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上海药物研究所 [15]
山东大学 [3]
过程工程研究所 [2]
湖南大学 [2]
重庆大学 [1]
南海海洋研究所 [1]
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期刊论文 [29]
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2018 [29]
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Design, synthesis, and bioactivity evaluation of novel Bcl-2/HDAC dual-target inhibitors for the treatment of multiple myeloma
期刊论文
Bioorganic & medicinal chemistry letters, 2018
作者:
Zhou, Ruolan
;
Fang, Shaoyu
;
Zhang, Minmin
;
Zhang, Qingsen
;
Hu, Jian
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浏览/下载:97/0
  |  
提交时间:2019/01/08
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Lu, Yu-Ting
;
Xiao, Yu-Feng
;
Li, Yu-Feng
;
Li, Jia
;
Nan, Fa-Jun
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  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
期刊论文
European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689
作者:
Wang, Qi
;
Dai, Yang
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浏览/下载:86/0
  |  
提交时间:2019/01/08
Real-Time Dissecting the Entry and Intracellular Dynamics of Single Reovirus Particle
期刊论文
FRONTIERS IN MICROBIOLOGY, 2018, 卷号: 9, 页码: 17
作者:
Zhang, Qi-Ya
;
Pang, Dai-Wen
;
Gui, Jian-Fang
;
Yu, Cong
;
Liu, Jia
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浏览/下载:50/0
  |  
提交时间:2018/12/29
non-enveloped virus
reovirus
entry
real-time
single-particle tracking
clathrin
cytoskeletons
endosomes
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
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  |  
浏览/下载:50/0
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提交时间:2019/01/08
Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment
期刊论文
ADVANCED MATERIALS, 2018, 卷号: 30, 期号: 38
作者:
Feng, Bing
;
Zhou, Fangyuan
;
Hou, Bo
;
Wang, Dangge
;
Wang, Tingting
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
immune tumor microenvironment
immunogenic cell death
immunotherapy
prodrug nanoparticles
stimuli-activation
Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 卷号: 175, 期号: 17, 页码: 3486-3503
作者:
Dong, Jiajia
;
Olaleye, Olajide E.
;
Jiang, Rongrong
;
Li, Jing
;
Lu, Chuang
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  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents
期刊论文
ACS chemical neuroscience, 2018
作者:
Xu, Yixiang
;
Zhang, Jian
;
Wang, Huan
;
Mao, Fei
;
Bao, Keting
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  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
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  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
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