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科研机构
上海药物研究所 [7]
湖南大学 [4]
四川大学 [3]
湖南中医药大学 [3]
新疆理化技术研究所 [1]
暨南大学 [1]
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期刊论文 [20]
发表日期
2018 [20]
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Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease
期刊论文
ACS chemical neuroscience, 2018
作者:
Wang, Huan
;
Zhang, Haiyan
收藏
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浏览/下载:59/0
  |  
提交时间:2019/01/08
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
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  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents
期刊论文
ACS chemical neuroscience, 2018
作者:
Xu, Yixiang
;
Zhang, Jian
;
Wang, Huan
;
Mao, Fei
;
Bao, Keting
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  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
Acetylcholinesterase Is a Potential Biomarker for a Broad Spectrum of Organic Environmental Pollutants
期刊论文
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 卷号: 52, 期号: 15, 页码: 8065-8074
作者:
Fu, Hualing
;
Xia, Yingjie
;
Chen, Yangshen
;
Xu, Tuan
;
Xu, Li
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  |  
浏览/下载:33/0
  |  
提交时间:2019/06/20
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
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  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Pharmacophore-based drug design for potential AChE inhibitors from Traditional Chinese Medicine Database
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 76, 期号: 2, 页码: 400-414
作者:
Jiang, YY (Jiang, Yingying)
;
Gao, HW (Gao, Hongwei)
;
Gao, HW
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  |  
浏览/下载:32/0
  |  
提交时间:2018/03/14
Ad
Ache
Flavonoids
Tcm
Pharmacophore Models
Docking
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and beta-amyloid aggregation inhibitory activities as potential agents against Alzheimer\'s disease
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: Vol.26 No.8, 页码: 1885-1895
作者:
Xu, R
;
Xiao, GY
;
Li, Y
;
Liu, HY
;
Song, Q
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/25
Alzheimer\'s disease
Benzo[d]isothiazol-3(2H)-one derivatives
Monoamine oxidase inhibitors
Acetylcholinesterase inhibitors
A beta aggregation inhibitors
Multifunctional agents
Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation.
期刊论文
Bioorganic chemistry, 2018, 卷号: Vol.84, 页码: 137-149
作者:
Song Qing
;
Li Yan
;
Cao Zhongcheng
;
Qiang Xiaoming
;
Tan Zhenghuai
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/25
Acetylcholinesterase
inhibitors
Alzheimer’s
disease
Anti-neuroinflammatory
agents
Antioxidant
Aβ
aggregation
inhibitors
Salicylamide
derivatives
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