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浏览/检索结果: 共22条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds 期刊论文 Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1902-1912 作者:  Gong, Grace Qun;  Wang, Ke;  Dai, Xin-Chuan;  Zhou, Yan;  Basnet, Rajesh 收藏  |  浏览/下载：98/0  |  提交时间：2019/01/08 Pharmacological characterization of hetrombopag, a novel orally active human thrombopoietin receptor agonist 期刊论文 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 卷号: 22, 期号: 11, 页码: 5367-5377 作者:  Xie, Chengying;  Zhao, Huajun;  Bao, Xubin;  Fu, Haoyu;  Lou, Liguang 收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08 eltrombopag  hetrombopag  hollow-fibre assay  thrombopoietin  thrombopoietin receptor   High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822 作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree 收藏  |  浏览/下载：84/0  |  提交时间：2019/01/08 high throughput screening  PI3 kinase  PI3K alpha H1047R  inhibitors  molecular modeling   Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3-Kinase alpha (PI3Kα) inhibitors 期刊论文 Chemical biology & drug design, 2018 作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Song, Kun;  Ruan, Cong 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Anticancer drug  Phosphatidylinositol 3-kinase  Structure-activity relationship   CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Fu, Xu-Hong;  Zhang, Xiong;  Yang, Hong;  Xu, Xiao-Wei;  Hu, Zong-Long 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Tang, Qing 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Proliferation  Anticancer drug  Phosphatidylinositol 3-kinase inhibitor  Apoptosis  Structure-activity relationship   Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention 期刊论文 ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 5, 页码: 767-771 作者:  Basnet, Rajesh;  Gong, Grace Qun;  Li, Chenyao;  Wang, Ming-Wei 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 SGK  AKT  PI3K  Cancer  Signalling: Kinase  Inhibitor   Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression 期刊论文 ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 8, 页码: 782-792 作者:  Yu, Dandan;  Zhang, Yong;  Chen, Gege;  Xie, Yongsheng;  Xu, Zhijian 收藏  |  浏览/下载：52/0  |  提交时间：2019/01/08 mantle cell lymphoma  pterostilbene  antiproliferative activity  PI3K/Akt/mTOR pathway  synergistic cytotoxicity   Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In Vivo 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2018, 卷号: 17, 期号: 7, 页码: 1540-1553 作者:  Song, Mengqiu;  Liu, Xuejiao;  Liu, Kangdong;  Zhao, Ran;  Huang, Hai 收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08