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浏览/检索结果: 共11条，第1-10条 帮助 限定条件 发表日期：2018    内容类型：期刊论文    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors 期刊论文 Cell reports, 2018, 卷号: 25, 期号: 13, 页码: 3582-3590.e4 作者:  Zhang, Jin-Bao;  Chang, Shenghai;  Xu, Pan;  Miao, Miao;  Wu, Hangjun 收藏  |  浏览/下载：118/0  |  提交时间：2019/01/08 Triple-Helix Conformation of a Polysaccharide Determined with Light Scattering, AFM, and Molecular Dynamics Simulation 期刊论文 MACROMOLECULES, 2018, 卷号: 51, 期号: 24, 页码: 10150-10159 作者:  Meng, Yan;  Shi, Xiaodan;  Cai, Liqin;  Zhang, Shihai;  Ding, Kan 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：101/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：130/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Zhang, Yi-Ting;  Yu, Yu-Qi;  Yan, Xiao-Xia;  Wang, Wen-Jie;  Tian, Xiao-Ting 收藏  |  浏览/下载：68/0  |  提交时间：2019/01/08 The effects of implicit modeling of nonpolar solvation on protein folding simulations 期刊论文 PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2018, 卷号: 20, 期号: 27, 页码: 18410-18419 作者:  Shao, Qiang;  Zhu, Weiliang 收藏  |  浏览/下载：8/0  |  提交时间：2019/01/08 Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 9, 页码: 1476-1483 作者:  Zhu, Kongkai;  Jiang, Chengshi;  Tao, Hongrui;  Liu, Jingqiu;  Zhang, Hua 收藏  |  浏览/下载：60/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Resynthesis  Virtual screening  Molecular docking  Molecular dynamics simulation   Assessing AMBER force fields for protein folding in an implicit solvent 期刊论文 PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2018, 卷号: 20, 期号: 10, 页码: 7206-7216 作者:  Shao, Oiang;  Zhu, Weiliang 收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 High-scalable Collaborated Parallel Framework for Large-scale Molecular Dynamic Simulation on Tianhe-2 Supercomputer 期刊论文 IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2018 作者:  Peng, Shaoliang;  Zhang, Xiaoyu;  Lu, Yutong;  Liao, Xiangke;  Lu, Kai 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727 作者:  Zhu, Kongkai;  Jiang, Cheng-Shi;  Hu, Junchi;  Liu, Xigong;  Yan, Xue 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 PRMT5 SAM competitive inhibitor  Molecular docking  Molecular dynamics simulation  Molecular mechanics/Poisson-Boltzmann surface area  PRMT5:MEP50 interaction