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上海药物研究所 [35]
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合肥物质科学研究院 [8]
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期刊论文 [107]
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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:
Li, Xin
;
Yang, Changyong
;
Wan, Hong
;
Zhang, Ge
;
Feng, Jun
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2019/01/08
Pyrotinib
HER2-postive breast cancer
Irreversible EGFR/HER2 dual tyrosine kinase
inhibitor
Preclinical
Clinical
Safety
Drug metabolism
Structure-Based Investigation on the Binding and Activation of Typical Pesticides With Thyroid Receptor
期刊论文
TOXICOLOGICAL SCIENCES, 2017, 卷号: 160, 期号: 2, 页码: 205-216
作者:
Xiang, Dandan
;
Han, Jian
;
Yao, Tingting
;
Wang, Qiangwei
;
Zhou, Bingsheng
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  |  
浏览/下载:29/0
  |  
提交时间:2019/07/03
pesticides
thyroid receptor
ligand binding assay
surface plasmon resonance
molecular docking
Polysaccharides and their depolymerized fragments from Costaria costata: Molecular weight and sulfation-dependent anticoagulant and FGF/FGFR signal activating activities
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 卷号: 105, 页码: 1511-1518
作者:
Hou, Ningning
;
Zhang, Meng
;
Xu, Yingjie
;
Sun, Zhongmin
;
Wang, Jing
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  |  
浏览/下载:90/0
  |  
提交时间:2018/01/11
Costaria Costata
Polysaccharide
Structure
Anticoagulant
Fibroblast Growth Factor (Fgf)
Fibroblast Growth Factor Receptor (Fgfr)
Extending the Structural View of Class B GPCRs
期刊论文
TRENDS IN BIOCHEMICAL SCIENCES, 2017, 卷号: 42, 期号: 12, 页码: 946-960
作者:
de Graaf, Chris
;
Song, Gaojie
;
Cao, Can
;
Zhao, Qiang
;
Wang, Ming-Wei
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  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum
期刊论文
FRONTIERS IN IMMUNOLOGY, 2017, 卷号: 8, 页码: 17
作者:
Jiang, Shuai
;
Wang, Lingling
;
Huang, Mengmeng
;
Jia, Zhihao
;
Weinert, Tobias
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  |  
浏览/下载:43/0
  |  
提交时间:2019/07/15
innate immunity
pattern recognition receptor
DM9 domain
crystal structure
mannose binding
phagocytosis
DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum
期刊论文
FRONTIERS IN IMMUNOLOGY, 2017, 卷号: 8
作者:
Jiang, Shuai
;
Wang, Lingling
;
Huang, Mengmeng
;
Jia, Zhihao
;
Weinert, Tobias
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2018/09/06
Innate Immunity
Pattern Recognition Receptor
Dm9 Domain
Crystal Structure
Mannose Binding
Phagocytosis
Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527
作者:
Chen, Lingfeng
;
Fu, Weitao
;
Feng, Chen
;
Qu, Rong
;
Tong, Linjiang
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  |  
浏览/下载:55/0
  |  
提交时间:2019/01/08
Epidermal growth factor receptor
Tyrosine kinase inhibitors
Non-small cell lung cancer
T790M
Mutant-selective
Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Ren, Zhizhong
;
Wang, Zhen
;
Zhou, X. Edward
;
Shi, Huazhong
;
Hong, Yechun
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  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer
期刊论文
ADVANCED SCIENCE, 2017, 卷号: 4, 期号: 10
作者:
Ni, Dezhi
;
Qing, Shuang
;
Ding, Hui
;
Yue, Hua
;
Yu, Di
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2017/11/27
Bacteria
Biomimetic Engineering
Cancer Immunotherapy
Particulate Adjuvant
Vaccines
Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 598-611
作者:
Qian, Hai-Yan
;
Wang, Zhi-Long
;
Xie, Xiao-Yu
;
Pan, You-Lu
;
Li, Gang-Jian
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Pyridazine-3-carboxamides
CB2 agonist
Structure-activity relationships
Molecular docking
logP
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