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科研机构
上海药物研究所 [2]
昆明植物研究所 [2]
高能物理研究所 [2]
海洋研究所 [2]
武汉大学 [2]
内容类型
期刊论文 [10]
发表日期
2017 [10]
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Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation
期刊论文
MARINE DRUGS, 2017, 卷号: 15, 期号: 11, 页码: 18
作者:
Wang, Li-Jun
;
Guo, Chuan-Long
;
Li, Xiang-Qian
;
Wang, Shuai-Yu
;
Jiang, Bo
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2019/07/15
bromophenol hybrids
anticancer
structure-activity relationships
ROS
apoptotic pathway
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells
期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 11, 页码: UNSP 1934
作者:
Song, Lihua
;
Wang, Zhe
;
Wang, Yurong
;
Guo, Di
;
Yang, Jianhong
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2018/05/08
Ra-xii
Cyclopeptide
Autophagy
Apoptosis
Mtor
Hepg2 Liver Cancer Cells
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531
作者:
Chen, Wenhua
;
Guo, Ne
;
Qi, Minghui
;
Dai, Haiying
;
Hong, Minghuang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Antitumor drug
BRCA1/2
PARP inhibitors
Molecular docking
A novel fluorinated thiosemicarbazone derivative-2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 491, 期号: 1, 页码: 65-71
作者:
Zhao, Yue
;
Guo, Chuanlong
;
Wang, Lijun
;
Wang, Shuaiyu
;
Li, Xiangqian
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2018/01/11
Thiosemicarbazone
Anticancer
2-(3
Apoptosis
4-difluorobenzylidene) Hydrazinecarbothioamide
Ros
Mitochondria-dependent Pathway
Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 1, 页码: 42434
作者:
Wei, Guangzheng
;
Tan, Dongdong
;
Chen, Chunmei
;
Tong, Qingyi
;
Li, Xiao-Nian
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2017/04/17
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
期刊论文
CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56
作者:
Yuan, Bo
;
Ye, Na
;
Song, Shan-Shan
;
Wang, Yu-Ting
;
Song, Zilan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Homologous recombination repair defects
Olaparib
Growth inhibition
Patient-derived xenografts
Pharmacokinetics
Mor-platin a new platinum complex that can induce apoptosis and inhibit migration
期刊论文
Chinese Science Bulletin科学通报, 2017, 卷号: 62, 期号: 4, 页码: 270-278
作者:
Li, Jingling
;
Cao, Jianping
;
Chen, Chunying
;
Guo, Zhengqing
;
Zhang, Leshuai
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/08/27
Mor-platin a new platinum complex that can induce apoptosis and inhibit migration
期刊论文
Chinese Science Bulletin科学通报, 2017, 卷号: 62, 期号: 4, 页码: 270-278
作者:
Li, Jingling
;
Chen CY(陈春英)
;
Cao, Jianping
;
Zhang, Leshuai
;
Guo, Zhengqing
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/08/29
PARP-1 Variant Rs1136410 Confers Protection against Coronary Artery Disease in a Chinese Han Population: A Two-Stage Case-Control Study Involving 5643 Subjects
期刊论文
FRONTIERS IN PHYSIOLOGY, 2017, 卷号: 8
作者:
Wang, Xue-bin
;
Cui, Ning-hua
;
Zhang, Shuai
;
Guo, Shu-ren
;
Liu, Ze-jin
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
PARP-1 rs1136410
PARP activities
coronary artery disease
severity of coronary atherosclerosis
gene-environment interactions
Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis
期刊论文
GENE, 2017, 卷号: 600
作者:
Cui, Ning-hua
;
Qiao, Chen
;
Chang, Xiao-ke
;
Wei, Li
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
rs1136410
PARP activity
Oxidative DNA damage
Age-related cataract
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