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科研机构
上海药物研究所 [25]
西安交通大学 [15]
复旦大学上海医学院 [10]
上海中医药大学 [8]
四川大学 [7]
山东大学 [7]
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期刊论文 [122]
会议论文 [8]
发表日期
2017 [130]
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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:
Li, Xin
;
Yang, Changyong
;
Wan, Hong
;
Zhang, Ge
;
Feng, Jun
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2019/01/08
Pyrotinib
HER2-postive breast cancer
Irreversible EGFR/HER2 dual tyrosine kinase
inhibitor
Preclinical
Clinical
Safety
Drug metabolism
Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1642-1654
作者:
Li, Jing-qiu
;
Wu, Xian
;
Gan, Lu
;
Yang, Xiang-liang
;
Miao, Ze-hong
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
hepatocellular carcinoma
hypoxia
5-fluorouracil
sorafenib
drug resistance
Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 101-112
作者:
Ji, Yue-Yang
;
Lin, Sen-Dong
;
Wang, Yu-Jie
;
Su, Ming-Bo
;
Zhang, Wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Tranylcypromine
LSD1
Stereoselective cyclopropanation
Chiral synthesis
MAO-A
MAO-B
Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans
期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:
Jiang, Jinfang
;
Chen, Xiaoyan
;
Zhong, Dafang
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
arylacetamide deacetylase
vicagrel
clopidogrel
hydrolytic metabolism
Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 8888-8905
作者:
Wang, Chen
;
Jiang, Hao
;
Jin, Jia
;
Xie, Yiqian
;
Chen, Zhifeng
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  |  
浏览/下载:113/0
  |  
提交时间:2019/01/08
Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3 x TgAD mice
期刊论文
NEUROPHARMACOLOGY, 2017, 卷号: 126, 页码: 200-212
作者:
Ke, Dan
;
Sun, Dong-Sheng
;
Gao, Li-Feng
;
Jin, Li
;
Wu, Hao
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2017/12/26
Fluoxetine
Alzheimer's Disease
Cognitive
Mri
Bdnf
Chemical constituents, and pharmacological and toxicological effects of Cynomorium songaricum: An overview
期刊论文
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 卷号: 16, 期号: 11, 页码: 2689-2696
作者:
Cheng, Dan
;
Zheng, Junchao
;
Ma, Suya
;
Murtaza, Ghulam
;
Wahab, Awais
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  |  
浏览/下载:87/0
  |  
提交时间:2019/12/16
Cynomorium
Chemical constituents
Inflammation
Aging
Fatigue
Virus
Tumor
Toxicological effect
Safety, Pharmacokinetics and Pharmacodynamics of Hetrombopag Olamine, a Novel TPO-R Agonist, in Healthy Individuals
期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2017, 卷号: 121, 期号: 5, 页码: 414-422
作者:
Zheng, Li
;
Liang, Mao-zhi
;
Zeng, Xiao-ling
;
Li, Cai-zheng
;
Zhang, Yi-fan
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152
作者:
Wang, Zhengyu
;
Shi, Xiaofan
;
Zhang, Huan
;
Yu, Liang
;
Cheng, Yanhua
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
Type 2 diabetes mellitus
Hypoglycemia
Dyslipidemia
Glucokinase activators
N-Thiazol-2-yl-benzamides
A systematic analysis of FDA-approved anticancer drugs
期刊论文
BMC SYSTEMS BIOLOGY, 2017, 卷号: 11, 页码: 27-43
作者:
Sun, Jingchun
;
Wei, Qiang
;
Zhou, Yubo
;
Wang, Jingqi
;
Liu, Qi
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Anticancer drugs
Drug-cancer network
Cancer-drug-target network
Drug repurposing
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