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浏览/检索结果: 共33条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun 收藏  |  浏览/下载：136/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor 期刊论文 STEM CELL REPORTS, 2017, 卷号: 9, 期号: 6, 页码: 1813-1824 作者:  Gao, Yimeng;  Zhang, Xiaoran;  Zhang, Ludi;  Cen, Jin;  Ni, Xuan 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 Critical Role of Hepatic Cyp450 sin the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice 期刊论文 FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8 作者:  Yu, Cunzhi;  Li, Yu;  Liu, Mingxia;  Gao, Man;  Li, Chenggang 收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 (5R)-5-hydroxytriptolide  functional knockout  cytochrome P450  testes  gamma-H2AX  RNA polymerase II  androgen receptor   Dissociative role for dorsal hippocampus in mediating heroin self-administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis 期刊论文 ADDICTION BIOLOGY, 2017, 卷号: 22, 期号: 6, 页码: 1731-1742 作者:  Chen, Zhong-Guo;  Liu, Xing;  Wang, Weisheng;  Geng, Fan;  Gao, Jing 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 CDK5  dorsal hippocampus  heroin self-administration  label-free proteomic analysis  RhoB  the centrifugal proteomic reactor   Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152 作者:  Wang, Zhengyu;  Shi, Xiaofan;  Zhang, Huan;  Yu, Liang;  Cheng, Yanhua 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 Type 2 diabetes mellitus  Hypoglycemia  Dyslipidemia  Glucokinase activators  N-Thiazol-2-yl-benzamides   Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531 作者:  Chen, Wenhua;  Guo, Ne;  Qi, Minghui;  Dai, Haiying;  Hong, Minghuang 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Antitumor drug  BRCA1/2  PARP inhibitors  Molecular docking   Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2017, 卷号: 57, 期号: 9, 页码: 2329-2335 作者:  Cai, Haiyan;  Wang, Ting;  Yang, Zhuo;  Xu, Zhijian;  Wang, Guimin 收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08 Amyloid beta: structure, biology and structure-based therapeutic development 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235 作者:  Chen, Guo-fang;  Xu, Ting-hai;  Yan, Yan;  Zhou, Yu-ren;  Jiang, Yi 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 amyloid beta peptide  amyloid precursor protein  Alzheimer's disease  neurodegenerative diseases  drug discovery   Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor 期刊论文 STEM CELL REPORTS, 2017, 卷号: 9, 期号: 2, 页码: 499-512 作者:  Guo, Ren;  Tang, Wei;  Yuan, Qianting;  Hui, Lijian;  Wang, Xin 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Multiple Dose Pharmacokinetics and Safety of Sulcardine Sulfate in Healthy Chinese Male Subjects: An Open-Label Phase I Clinical Study 期刊论文 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2017, 卷号: 42, 期号: 4, 页码: 593-599 作者:  Wang, Wei;  Qian, Hong-jie;  Xin, Liang;  Zhang, Meng-qi;  Lu, Dong-ying 收藏  |  浏览/下载：12/0  |  提交时间：2019/01/08