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浏览/检索结果: 共40条，第1-10条 帮助 限定条件 发表日期：2017    内容类型：期刊论文    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun 收藏  |  浏览/下载：136/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans 期刊论文 ARCHIVES OF TOXICOLOGY, 2017, 卷号: 91, 期号: 12, 页码: 3913-3925 作者:  Yang, Mengbi;  Ruan, Jianqing;  Gao, Hong;  Li, Na;  Ma, Jiang 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Pyrrolizidine alkaloid N-oxide  Pyrrolizidine alkaloid  Hepatic sinusoidal obstruction syndrome  Pyrrole-protein adduct  Biotransformation  Toxicokinetic   Critical Role of Hepatic Cyp450 sin the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice 期刊论文 FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8 作者:  Yu, Cunzhi;  Li, Yu;  Liu, Mingxia;  Gao, Man;  Li, Chenggang 收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 (5R)-5-hydroxytriptolide  functional knockout  cytochrome P450  testes  gamma-H2AX  RNA polymerase II  androgen receptor   PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII alpha, Inhibits the Growth of Breast Cancer Cells 期刊论文 CANCER RESEARCH, 2017, 卷号: 77, 期号: 22, 页码: 6253-6266 作者:  Li, Jiangmei;  Gao, Zhen;  Zhao, Dan;  Zhang, Lunfeng;  Qiao, Xinhua 收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08 Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527 作者:  Chen, Lingfeng;  Fu, Weitao;  Feng, Chen;  Qu, Rong;  Tong, Linjiang 收藏  |  浏览/下载：55/0  |  提交时间：2019/01/08 Epidermal growth factor receptor  Tyrosine kinase inhibitors  Non-small cell lung cancer  T790M  Mutant-selective   Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals 期刊论文 CRYSTENGCOMM, 2017, 卷号: 19, 期号: 41, 页码: 6154-6163 作者:  He, Hongyan;  Zhang, Qi;  Wang, Jian-Rong;  Mei, Xuefeng 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson's Disease 期刊论文 MOLECULAR NEUROBIOLOGY, 2017, 卷号: 54, 期号: 9, 页码: 6970-6983 作者:  Wu, Qimei;  Yang, Xiaoyu;  Zhang, Lei;  Zhang, Yu;  Feng, Linyin 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 HDAC4  alpha-Synuclein  Neuroprotection  Parkinson's disease  PKC   Design and synthesis of pregnenolone/2-cyanoacryloyl conjugates with dual NF-kappa B inhibitory and anti-proliferative activities 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 20, 页码: 4682-4686 作者:  Song, Jia-Li;  Zhang, Juan;  Liu, Chang-Liang;  Liu, Chao;  Zhu, Kong-Kai 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Pregnenolone  NF-kappa B  2-Cyanoacryloyl  Michael acceptor  Anti-proliferative activity   Synthesis and biological evaluation of benzothiazol-based 1,3,4-oxadiazole derivatives as amyloid beta-targeted compounds against Alzheimer's disease 期刊论文 MONATSHEFTE FUR CHEMIE, 2017, 卷号: 148, 期号: 10, 页码: 1807-1815 作者:  Mei, Wen-wen;  Ji, Sha-sha;  Xiao, Wei;  Wang, Xue-dong;  Jiang, Cheng-shi 收藏  |  浏览/下载：62/0  |  提交时间：2019/01/08 Structure-activity relationships  Heterocycles  Drug research  Neuroprotective effects