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浏览/检索结果: 共6条，第1-6条 帮助 限定条件 发表日期：2013    专题：中南大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 MicroRNAs: a new piece in the paediatric cardiovascular disease puzzle. 期刊论文 Cardiology in the Young, 2013, 卷号: 23, 期号: 5, 页码: 642-655 作者:  Omran, Ahmed;  Elimam, Dalia;  Webster, Keith A.;  Shehadeh, Lina A.;  Yin, Fei* 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03 MicroRNAs  biomarker  cardiac stem cells  paediatric cardiovascular diseases  therapeutic target   Hsp27: A novel therapeutic target for pediatric M4/M5 acute myeloid leukemia 期刊论文 Oncology Reports, 2013, 卷号: 29, 期号: 4, 页码: 1459-1466 作者:  Yang, Liangchun;  Cao, Lizhi;  Yang, Minghua;  Tang, Daolin;  Kang, Rui 收藏  |  浏览/下载：1/0  |  提交时间：2019/12/03 heat shock protein 27  pediatric acute leukemia  M4/M5  chemosensitivity   A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells 期刊论文 Experimental and Therapeutic Medicine, 2013, 卷号: 5, 期号: 4, 页码: 1143-1146 作者:  Fan, Min;  Li, Xinying*;  Jiang, Wei;  Huang, Yun;  Li, Jingdong 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 miR-574-5p  papillary thryoid susceptibility candidate 3  thyroid cancer   The Nuclear Factor Kappa-B Signaling Pathway as a Therapeutic Target Against Thyroid Cancers 期刊论文 Thyroid : official journal of the American Thyroid Association, 2013, 卷号: 23, 期号: 2, 页码: 209-218 作者:  Li, Xinying;  Abdel-Mageed, Asim B.;  Mondal, Debasis;  Kandil, Emad* 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03 The CD40/CD4OL system: A new therapeutic target for disease 期刊论文 IMMUNOLOGY LETTERS, 2013, 卷号: 153, 期号: 1-2, 页码: 58-61 作者:  Zhang, Bikui;  Wu, Tian;  Chen, Min;  Zhou, Yulu;  Yi, Dongyang 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 CD40/CD4OL  Monoclonal antibodies (mAbs)  Statins  Clopidogrel  SGN-40   Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文 International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118 作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.