Aberration correction during real time in vivo imaging of bone marrow with sensorless adaptive optics confocal microscope

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	Aberration correction during real time in vivo imaging of bone marrow with sensorless adaptive optics confocal microscope
	Wang, Zhibin 1,2,3; Wei, Dan 4,5; Wei, Ling 1,2; He, Yi 1,2; Shi, Guohua 1,2; Wei, Xunbin 4,5; Zhang, Yudong 1,2
刊名	JOURNAL OF BIOMEDICAL OPTICS
	2014-08-01
卷号	19 期号:8
关键词	adaptive optics in vivo imaging mouse bone marrow fluorescence aberration correct
英文摘要	We have demonstrated adaptive correction of specimen-induced aberration during in vivo imaging of mouse bone marrow vasculature with confocal fluorescence microscopy. Adaptive optics system was completed with wavefront sensorless correction scheme based on stochastic parallel gradient descent algorithm. Using image sharpness as the optimization metric, aberration correction was performed based upon Zernike polynomial modes. The experimental results revealed the improved signal and resolution leading to a substantially enhanced image contrast with aberration correction. The image quality of vessels at 38- and 75-mu m depth increased three times and two times, respectively. The corrections allowed us to detect clearer bone marrow vasculature structures at greater contrast and improve the signal-to-noise ratio. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	WAVE-FRONT SENSOR ; 2-PHOTON MICROSCOPY
收录类别	SCI
语种	英语
WOS记录号	WOS:000341250300024
公开日期	2015-12-24
内容类型	期刊论文
源URL	[http://ir.ioe.ac.cn/handle/181551/2512]
专题	光电技术研究所_光电技术研究所被WoS收录文章
作者单位	1.Chinese Acad Sci, Key Lab Adapt Opt, Chengdu 610209, Peoples R China 2.Chinese Acad Sci, Inst Opt & Elect, Lab Adapt Opt, Chengdu 610209, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China 5.Med X Res Inst, Shanghai 200030, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhibin,Wei, Dan,Wei, Ling,et al. Aberration correction during real time in vivo imaging of bone marrow with sensorless adaptive optics confocal microscope[J]. JOURNAL OF BIOMEDICAL OPTICS,2014,19(8).
APA	Wang, Zhibin.,Wei, Dan.,Wei, Ling.,He, Yi.,Shi, Guohua.,...&Zhang, Yudong.(2014).Aberration correction during real time in vivo imaging of bone marrow with sensorless adaptive optics confocal microscope.JOURNAL OF BIOMEDICAL OPTICS,19(8).
MLA	Wang, Zhibin,et al."Aberration correction during real time in vivo imaging of bone marrow with sensorless adaptive optics confocal microscope".JOURNAL OF BIOMEDICAL OPTICS 19.8(2014).