Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes
	Yu, KC ; Wan, FX ; Zhang, Y ; Zhou, JL ; Lu, G ; Liu, ML ; Ding, SW
刊名	CHINESE JOURNAL OF INORGANIC CHEMISTRY
	2004-04-01
卷号	20 期号:4 页码:389-393
关键词	ester-amid gadolinium complex liver-selecting contrast agent relaxivity T-1-weighted imaging
英文摘要	Four new ester-amido ligands were synthesized by esterification of mono-iso-butyl diethylenetriaminepentaacetate and mono-iso-butyl ethylenediaminetetraacetate with N,N'-ethylene bis-lactamide and NN'-1,6-hexamethylenebislactamide, respectively. The corresponding Gd(III) complexes were made by reacting the ligands with Gd2O3. All ligands and complexes were characterized: by FT-IR, H-1 NMR and elemental analysis. The measured longitudinal relaxivity of these complexes were all higher than that of Gd-DTPA. The investigation on cute toxicity and T-1-weighted imaging of complex derived from mono-N,N'-ethylenebislactamide ester diethlenetriaminepentaacetate were performed. No cute toxicity was found. The tested complex exhibited the higher enhancement on MRI signal intensity in rat liver, comparing with Gd-DTPA.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Inorganic & Nuclear
研究领域[WOS]	Chemistry
关键词[WOS]	AGENTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000220795100004
公开日期	2015-12-08
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9004]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan 4.Natl Sun Yat Sen Univ, Ctr Nanosci & Nanotechnol, Kaohsiung 80424, Taiwan
推荐引用方式 GB/T 7714	Yu, KC,Wan, FX,Zhang, Y,et al. Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2004,20(4):389-393.
APA	Yu, KC.,Wan, FX.,Zhang, Y.,Zhou, JL.,Lu, G.,...&Ding, SW.(2004).Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes.CHINESE JOURNAL OF INORGANIC CHEMISTRY,20(4),389-393.
MLA	Yu, KC,et al."Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes".CHINESE JOURNAL OF INORGANIC CHEMISTRY 20.4(2004):389-393.