Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species

	Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species
	Liu, Hong-Tao 1; Du, Yu-Guang 2; He, Jun-Lin 3; Chen, Wen-Juan 1; Li, Wen-Ming 1; Yang, Zhu 1; Wang, Ying-Xiong 1; Yu, Chao 1
刊名	journal of ethnopharmacology
	2010-06-16
卷号	129 期号:3 页码:335-343
关键词	Tetramethylpyrazine Inflammation Inducible nitric oxide synthase Microglial cell Mitogen-activated protein kinase PI3-kinase
英文摘要	aim of the study: to determine the inhibitory effect of tetramethylpyrazine (tmp) on lipopolysaccharide (lps)-induced over-production of nitric oxide (no) and inducible nitric oxide synthase (inos) in n9 microglial cells.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; integrative & complementary medicine ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy ; integrative & complementary medicine
关键词[WOS]	vascular endothelial-cells ; protein-kinase pathways ; necrosis-factor-alpha ; nf-kappa-b ; activated microglia ; adhesion molecules ; induced expression ; interferon-gamma ; gene-expression ; nadph oxidase
收录类别	SCI
语种	英语
WOS记录号	WOS:000279439300008
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141865]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China
推荐引用方式 GB/T 7714	Liu, Hong-Tao,Du, Yu-Guang,He, Jun-Lin,et al. Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species[J]. journal of ethnopharmacology,2010,129(3):335-343.
APA	Liu, Hong-Tao.,Du, Yu-Guang.,He, Jun-Lin.,Chen, Wen-Juan.,Li, Wen-Ming.,...&Yu, Chao.(2010).Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species.journal of ethnopharmacology,129(3),335-343.
MLA	Liu, Hong-Tao,et al."Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species".journal of ethnopharmacology 129.3(2010):335-343.