CONVENIENT SYNTHESIS OF OPTICALLY PURE 8-METHOXY-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE AND 2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE

	CONVENIENT SYNTHESIS OF OPTICALLY PURE 8-METHOXY-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE AND 2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE
	Tang, Jie 1; Jiang, Guo-Fang 1; Zhou, Yong-Gui 2
刊名	heterocycles
	2010-12-31
卷号	82 期号:1 页码:887-893
关键词	Chemical Resolution Hydrogenation Chiral Tetrahydroquinoline
英文摘要	a convenient method was developed to synthesize optically pure 8-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline (2a) and 2-methyl-1,2,3,4-tetrahydroquinoline (2b) by combining the methods of catalytic hydrogenation and classical resolution. the catalytic system ([ru(p-cymene)cl(2)](2)/i(2)) showed high efficiency in preparing racemic 2a and 2b, which were successfully resolved using commercial tartaric acid derivatives, and both enantiomers were obtained in moderate yield with >99% ee.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	iridium-catalyzed hydrogenation ; asymmetric hydrogenation ; galipea-officinalis ; heteroaromatic-compounds ; kinetic resolution ; quinolines ; alkaloids ; (+/-)-2-methyl-1,2,3,4-tetrahydroquinoline ; (+/-)-2-methylindoline ; ligands
收录类别	SCI
语种	英语
WOS记录号	WOS:000286906100064
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141833]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Tang, Jie,Jiang, Guo-Fang,Zhou, Yong-Gui. CONVENIENT SYNTHESIS OF OPTICALLY PURE 8-METHOXY-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE AND 2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE[J]. heterocycles,2010,82(1):887-893.
APA	Tang, Jie,Jiang, Guo-Fang,&Zhou, Yong-Gui.(2010).CONVENIENT SYNTHESIS OF OPTICALLY PURE 8-METHOXY-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE AND 2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE.heterocycles,82(1),887-893.
MLA	Tang, Jie,et al."CONVENIENT SYNTHESIS OF OPTICALLY PURE 8-METHOXY-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE AND 2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE".heterocycles 82.1(2010):887-893.