Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector

	Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector
	Li, GB ; Lin, XL ; Zhu, CF ; Wu, P
刊名	chinese journal of analytical chemistry
	2000-10-01
卷号	28 期号:10 页码:1287-1290
关键词	enantioseparation chiral drugs L-glutamine capillary electrophoresis
英文摘要	a rapid separation method using l-glutamine as chiral selector was set up. ten kinds of racemates, such as propranolol, mexiletine, propafenone, eprajinone, isoprenaline, ketamine, anisodamine, lobeline, bupivacaine, benzhexol ect. were successfully separated by choosing the best separating conditions. the use of borax and l-glutamine as buffer additive was found to be effective for the chiral separation. the ph of the background electrolyte and the concentrations of chiral selector and borax were optimized. in a solution containing 60 mmol/l l-glutamine and 60 mmol/l borax (ph = 9.25), the ten drugs were baseline separated in less than 11 minutes. the separating mechanism was also discussed.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, analytical
研究领域[WOS]	chemistry
关键词[WOS]	zone-electrophoresis ; cyclodextrin ; separation
收录类别	SCI
语种	英语
WOS记录号	WOS:000165083400025
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/138746]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Shandong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
推荐引用方式 GB/T 7714	Li, GB,Lin, XL,Zhu, CF,et al. Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector[J]. chinese journal of analytical chemistry,2000,28(10):1287-1290.
APA	Li, GB,Lin, XL,Zhu, CF,&Wu, P.(2000).Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector.chinese journal of analytical chemistry,28(10),1287-1290.
MLA	Li, GB,et al."Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector".chinese journal of analytical chemistry 28.10(2000):1287-1290.