Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage

	Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage
	Liu, Han 1; Wu, Hui 1,2; Kuwada, Takao 4; Okada, Hiroyuki 4; Cong, Wei 1; Wang, Xiaoying 1,5; Sun, Guangwei 3; Xu, Xiaoxi 3; Sakae, Toshiro 4; Xiao, Jing 1
刊名	journal of hard tissue biology
	2012-04-01
卷号	21 期号:2 页码:173-179
关键词	Retinoic acid Cleft palate Wnt Signals Animal model Perinatal stage
英文摘要	signaling pathways have been shown to participate in the process of retinoic acid (ra) - induced cleft palate (cp). in our current study, the signaling molecules of gsk-3 beta, fzd3 and beta-trcp, which all relate with wnt pathway, were screened from the palate tissues of the ra-induced cp in mice by the gene-chip technology. but, their expression pattern and level in palates during perinatal stages have not been known yet. in the studies, mrna level of gsk-3 beta, fzd3 and beta-trcp were detected by quantitative real-time pcr, and showed significant difference between the embryonic day 18 (ed18) before birth and postnatal day 0 (pd0) after birth, as well as between the ra-induced cp and wild type during the perinatal stage, respectively. and the localization pattern of gsk-3 beta, fzd3 and beta-trcp proteins in palates was also characterized. our data indicates that the wnt signaling pathway may involve in the ra-induced cleft palate during peirnatal stage.
WOS标题词	science & technology ; technology
类目[WOS]	engineering, biomedical
研究领域[WOS]	engineering
关键词[WOS]	tissue ; regeneration ; receptor ; gsk-3 ; mice
收录类别	SCI
语种	英语
WOS记录号	WOS:000304867000012
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/138097]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Dept Oral Biol, Coll Stomatol, Dalian 116044, Peoples R China 2.Hainan Med Collage Hosp, Dept Stomatol, Haikou, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 4.Nihon Univ, Sch Dent Matsudo, Dept Histol, Matsudo, Chiba, Japan 5.China Natl Pwtroleum Corp, Cent Hosp, Dept Stomatol, Langfang, Peoples R China
推荐引用方式 GB/T 7714	Liu, Han,Wu, Hui,Kuwada, Takao,et al. Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage[J]. journal of hard tissue biology,2012,21(2):173-179.
APA	Liu, Han.,Wu, Hui.,Kuwada, Takao.,Okada, Hiroyuki.,Cong, Wei.,...&Xiao, Jing.(2012).Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage.journal of hard tissue biology,21(2),173-179.
MLA	Liu, Han,et al."Expression of Signaling Molecules Related to Wnt Pathway in Cleft Palate Induced by Retinoic Acid during Perinatal Stage".journal of hard tissue biology 21.2(2012):173-179.