Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1

	Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1
	Peter, Christoph 1,7; Waibel, Michaela 1; Keppeler, Hildegard 1; Lehmann, Rainer 2; Xu, Guowang 5; Halama, Anna 6; Adamski, Jerzy 6; Schulze-Osthoff, Klaus 3; Wesselborg, Sebastian 1,7; Lauber, Kirsten 1,4
刊名	autoimmunity
	2012-12-01
卷号	45 期号:8 页码:568-573
关键词	Apoptosis chemotaxis 'find-me' signal lysophosphatidylcholine ATP-binding cassette transporter
英文摘要	efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. a major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (lpc). so far, however, the mechanisms underlying lpc release are poorly understood. in this study, we demonstrate that pharmacological inhibition and rnai-mediated knock-down of the lipid transporter abca1 in apoptotic cells completely abolished phagocyte attraction. moreover, ectopic expression of abca1 significantly enhanced monocyte migration to supernatants of apoptotic cells. hence, abca1 represents a novel regulator of lpc release during apoptosis.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	immunology
研究领域[WOS]	immunology
关键词[WOS]	tangier-disease ; cell-death ; engulfment ; clearance ; phagocytosis ; migration ; elegans ; abc1 ; act
收录类别	SCI
语种	英语
WOS记录号	WOS:000310148300002
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/138091]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Univ Tubingen, Dept Internal Med 1, Tubingen, Germany 2.Univ Tubingen, Dept Internal Med 4, Tubingen, Germany 3.Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany 4.Univ Munich, Dept Radiat Oncol, Munich, Germany 5.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 6.Helmholtz Ctr Munich, Genome Anal Ctr, Inst Expt Genet, Munich, Germany 7.Univ Dusseldorf, Inst Mol Med, D-40225 Dusseldorf, Germany
推荐引用方式 GB/T 7714	Peter, Christoph,Waibel, Michaela,Keppeler, Hildegard,et al. Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1[J]. autoimmunity,2012,45(8):568-573.
APA	Peter, Christoph.,Waibel, Michaela.,Keppeler, Hildegard.,Lehmann, Rainer.,Xu, Guowang.,...&Lauber, Kirsten.(2012).Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.autoimmunity,45(8),568-573.
MLA	Peter, Christoph,et al."Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1".autoimmunity 45.8(2012):568-573.