A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications

	A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications
	Ge, Guang-Bo 1; Ning, Jing 1,2; Hu, Liang-Hai 3; Dai, Zi-Ru 1; Hou, Jie 2; Cao, Yun-Feng 1; Yu, Zhen-Wen 1; Ai, Chun-Zhi 1; Gu, Jing-Kai 3; Ma, Xiao-Chi 2
刊名	chemical communications
	2013
卷号	49 期号:84 页码:9779-9781
英文摘要	bufalin 5 beta-hydroxylation was found to be an isoform-specific biotransformation probe substrate for cytochrome p450 3a4 (cyp3a4). the probe reaction was well-characterized and it can be used for measuring the real catalytic activities of cyp3a4 from different enzyme sources.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	in-vitro ; cyp3a5 ; inhibition ; metabolism ; mechanism ; polymorphisms ; expression ; drugs
收录类别	SCI
语种	英语
WOS记录号	WOS:000324928000022
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/137709]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China 2.Dalian Med Univ, Dalian, Peoples R China 3.Jilin Univ, Res Ctr Drug Metab, Coll Life Sci, Changchun 130023, Peoples R China
推荐引用方式 GB/T 7714	Ge, Guang-Bo,Ning, Jing,Hu, Liang-Hai,et al. A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications[J]. chemical communications,2013,49(84):9779-9781.
APA	Ge, Guang-Bo.,Ning, Jing.,Hu, Liang-Hai.,Dai, Zi-Ru.,Hou, Jie.,...&Yang, Ling.(2013).A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications.chemical communications,49(84),9779-9781.
MLA	Ge, Guang-Bo,et al."A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications".chemical communications 49.84(2013):9779-9781.