Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate

	Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate
	Sun, Tingting 1,2; Guan, Xingang 1,3; Zheng, Min 4; Jing, Xiabin 1; Xie, Zhigang 1
刊名	ACS MEDICINAL CHEMISTRY LETTERS
	2015-04-01
卷号	6 期号:4 页码:430-433
关键词	BODIPY cisplatin mitochondria imaging
英文摘要	A convenient synthesis of a BODIPY (1,3,5,7-tetramethyl-8-(4-pyridyl)-4,4'-difluoroboradiazaindacene) labeled platinum compound (BODIPY-Pt) was developed by direct conjugation of cisplatin with the pyridine group of BODIPY. The membrane permeability and selective uptake of BODIPY-Pt in the mitochondria was studied using confocal laser scanning microscopy (CLSM). The fluorescent BODIPY-Pt conjugate showed high cellular proliferation inhibition against human cervical carcinoma (HeLa) and human breast cancer (MCF-7) cells, with half maximal inhibitory concentrations (IC50) of 27.37 and 12.14 mu M, respectively. This work highlights the potential of using BODIPY labeled Pt compounds to realize the visualization of Pt distribution in living cells.
收录类别	SCI
语种	英语
公开日期	2015-11-03
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28620]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beihua Univ, Life Sci Res Ctr, Fengman 132013, Jilin, Peoples R China 4.Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Luminescence & Applicat, Changchun 130033, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Sun, Tingting,Guan, Xingang,Zheng, Min,et al. Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate[J]. ACS MEDICINAL CHEMISTRY LETTERS,2015,6(4):430-433.
APA	Sun, Tingting,Guan, Xingang,Zheng, Min,Jing, Xiabin,&Xie, Zhigang.(2015).Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate.ACS MEDICINAL CHEMISTRY LETTERS,6(4),430-433.
MLA	Sun, Tingting,et al."Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate".ACS MEDICINAL CHEMISTRY LETTERS 6.4(2015):430-433.