A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis

	A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis
	Lv, Yang 1; Li, Ailing 2; Zhou, Fang 1; Pan, Xiaoyu 3; Liang, Fuxin 2; Qu, Xiaozhong 4; Qiu, Dong 2; Yang, Zhenzhong 2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-06-03
卷号	7 期号:21 页码:11280-11285
关键词	PMMA bone cement phase-change microcapsule thermal necrosis setting time compressive strength modulus
英文摘要	Percutaneous vertebroplasty (VP) and balloon kyphoplasty (BKP) are now widely used to treat patients who suffer painful vertebral compression fractures. In each of these treatments, a bone cement paste is injected into the fractured vertebral body/bodies, and the cement of choice is a poly(methyl methacrylate) (PMMA) bone cement. One drawback of this cement is the very high exothermic temperature, which, it has been suggested, causes thermal necrosis of surrounding tissue. In the present work, we prepared novel composite PMMA bone cement where microcapsules containing a phase change material (paraffin) (PCMc) were mixed with the powder of the cement. A PCM absorbs generated heat and, as such, its presence in the cement may lead to reduction in thermal necrosis. We determined a number of properties of the composite cement. Compared to the values for a control cement (a commercially available PMMA cement used in VP and BKP), each composite cement was found to have significantly lower maximum exothermic temperature, increased setting time, significantly lower compressive strength, significantly lower compressive modulus, comparable biocompatibility, and significantly smaller thermal necrosis zone. Composite cement containing 20% PCMc may be suitable for use in VP and BKP and thus deserves further evaluation.
收录类别	SCI
语种	英语
公开日期	2015-11-02
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28194]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Peking Univ, Dept Orthoped, Hosp 3, Beijing 100191, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Soochow Univ, Coll Med, Suzhou 215123, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lv, Yang,Li, Ailing,Zhou, Fang,et al. A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(21):11280-11285.
APA	Lv, Yang.,Li, Ailing.,Zhou, Fang.,Pan, Xiaoyu.,Liang, Fuxin.,...&Yang, Zhenzhong.(2015).A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis.ACS APPLIED MATERIALS & INTERFACES,7(21),11280-11285.
MLA	Lv, Yang,et al."A Novel Composite PMMA-based Bone Cement with Reduced Potential for Thermal Necrosis".ACS APPLIED MATERIALS & INTERFACES 7.21(2015):11280-11285.