Synthesis of multi-substituted 4-aminopyridines via ring-opening and recyclization reactions of 2-iminopyridines

	Synthesis of multi-substituted 4-aminopyridines via ring-opening and recyclization reactions of 2-iminopyridines
	Zhou, Fenguo ; Zhang, Ning ; Xin, Xiaoqing ; Zhang,Xun ; Liang,Yongjiu ; Zhang,Rui ; Dong,Dewen
刊名	rsc advances
	2014
卷号	4 期号:35 页码:18198-18204
关键词	1 PYRIDINIUM SALTS DERIVATIVES SUBSTITUENT MALONONITRILE PINACIDIL CYCLOTRIMERIZATION ROFLUMILAST CROMAKALIM TORSEMIDE 3-SULFONYL SHIFT
通讯作者	liang,yj
英文摘要	a novel synthesis of multi-substituted 4-aminopyridines from 2-iminopyridines by a two-step procedure is described. during this transformation, 4-amino-2-iminopyridines undergo a regioselective ring-opening reaction in the presence of koh in t-butanol to afford 5-oxo-pent-3-enimidamides, which are then converted into 4-aminopyridines in toluene under reflux following a 6 pi-azaelectrocyclization and n-to-n 1,3-sulfonyl group migration mechanism.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57261]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhou, Fenguo,Zhang, Ning,Xin, Xiaoqing,et al. Synthesis of multi-substituted 4-aminopyridines via ring-opening and recyclization reactions of 2-iminopyridines[J]. rsc advances,2014,4(35):18198-18204.
APA	Zhou, Fenguo.,Zhang, Ning.,Xin, Xiaoqing.,Zhang,Xun.,Liang,Yongjiu.,...&Dong,Dewen.(2014).Synthesis of multi-substituted 4-aminopyridines via ring-opening and recyclization reactions of 2-iminopyridines.rsc advances,4(35),18198-18204.
MLA	Zhou, Fenguo,et al."Synthesis of multi-substituted 4-aminopyridines via ring-opening and recyclization reactions of 2-iminopyridines".rsc advances 4.35(2014):18198-18204.