Proteomic Analysis of Serum Proteins in Triple Transgenic Alzheimer's Disease Mice: Implications for Identifying Biomarkers for Use to Screen Potential Candidate Therapeutic Drugs for Early Alzheimer's Disease

	Proteomic Analysis of Serum Proteins in Triple Transgenic Alzheimer's Disease Mice: Implications for Identifying Biomarkers for Use to Screen Potential Candidate Therapeutic Drugs for Early Alzheimer's Disease
	Sui, Xiaojing ; Ren, Xiaohu ; Huang, Peiwu ; Li,Shuming ; Ma,Quan ; Ying,Ming ; Ni,Jiazuan ; Liu,Jianjun ; Yang,Xifei
刊名	journal of alzheimers disease
	2014
卷号	40 期号:3 页码:575-586
关键词	AMYLOID-BETA CEREBROSPINAL-FLUID PLASMA BIOMARKERS OXIDATIVE STRESS COENZYME Q(10) MOUSE MODEL AD PATIENTS TRANSTHYRETIN CSF ALPHA-2-MACROGLOBULIN
通讯作者	yang,xf
英文摘要	alzheimer's disease (ad) is the most common fatal neurodegenerative disease affecting the elderly worldwide. there is an urgent need to identify novel biomarkers of early ad. this study aims to search for potential early protein biomarkers in serum from a triple transgenic (ps1(m146)v/app(swe)/t-aup301l) mouse model. proteomic analysis via two-dimensional fluorescence difference gel electrophoresis was performed on serum samples from wild-type (wt) and triple transgenic mice that were treated with or without coenzyme q10 (coq10) (800 mg/kg body weight/day), a powerful endogenous antioxidant displaying therapeutic benefits against ad pathology and cognitive impairment in multiple ad mouse models, for a period of three months beginning at two months of age. a total of 15 differentially expressed serum proteins were identified between the wt and ad transgenic mice. the administration of coq10 was found to alter the changes in the differentially expressed serum proteins by upregulating 10 proteins and down-regulating 10 proteins. among the proteins modulated by coq10, clusterin and alpha-2 macroglobulin were validated via elisa assay. these findings revealed significant changes in serum proteins in the ad mouse model at an early pathological stage and demonstrated that administration of coq10 could modulate these changes in serum proteins. our study suggested that these differentially expressed serum proteins could serve as potential protein biomarkers of early ad and that screening for potential candidate ad therapeutic drugs and monitoring of therapeutic effects could be performed via measurement of the changes in these differentially expressed serum proteins.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57204]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Sui, Xiaojing,Ren, Xiaohu,Huang, Peiwu,et al. Proteomic Analysis of Serum Proteins in Triple Transgenic Alzheimer's Disease Mice: Implications for Identifying Biomarkers for Use to Screen Potential Candidate Therapeutic Drugs for Early Alzheimer's Disease[J]. journal of alzheimers disease,2014,40(3):575-586.
APA	Sui, Xiaojing.,Ren, Xiaohu.,Huang, Peiwu.,Li,Shuming.,Ma,Quan.,...&Yang,Xifei.(2014).Proteomic Analysis of Serum Proteins in Triple Transgenic Alzheimer's Disease Mice: Implications for Identifying Biomarkers for Use to Screen Potential Candidate Therapeutic Drugs for Early Alzheimer's Disease.journal of alzheimers disease,40(3),575-586.
MLA	Sui, Xiaojing,et al."Proteomic Analysis of Serum Proteins in Triple Transgenic Alzheimer's Disease Mice: Implications for Identifying Biomarkers for Use to Screen Potential Candidate Therapeutic Drugs for Early Alzheimer's Disease".journal of alzheimers disease 40.3(2014):575-586.