Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery

	Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery
	He, Hongyan ; Xiao, Haihua ; Kuang, Huihui ; Xie,Zhigang ; Chen,Xuesi ; Jing,Xiabin ; Huang,Yubin
刊名	colloids and surfaces b-biointerfaces
	2014
卷号	117 期号:9 页码:75-81
关键词	Mesoporous silica nanoparticles (MSN) Oxaliplatin Conjugates Thiol-ene click Drug delivery
通讯作者	huang,yb
英文摘要	mesoporous silica nanoparticles (msn) with 1,2-bidentate carboxyl groups on the surface reacted with 1,2-diaminecyclohexano platinum(ii) dinitrate (dach-pt-(no3)2) which is an active anticancer species of clinic relevant oxaliplatin to form msn-pt. the modification of the parent particles was monitored by c-13, si-29 solid-state nmr, x-ray measurements (xrd) and fourier transform infrared spectroscopy (ft-ir). after loading with platinum drugs, msn-pt exhibited two strong pt-4f signals as indicated by x-ray photoelectron spectroscopy (xps). the platinum content in the conjugates was calculated to be 9.7% according to icp-ms measurements. confocal laser scanning microscopy (clsm) displayed that msn-pt were uptaken fast by hepg-2 cells and concentrated within endosomes and lysosomes. in vitro mu assay of msn-pt demonstrated an improved cytotoxicity against hepg-2 cells than that of free oxaliplatin. this is due to the fact that msn-pt expressed higher platinum intracellular uptake and more dna binding (pt-dna adducts) than free oxaliplatin. hence this work highlighted that the platinum loaded msn nanoparticles could be a promising future intelligent drug delivery system. (c) 2014 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57202]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	He, Hongyan,Xiao, Haihua,Kuang, Huihui,et al. Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery[J]. colloids and surfaces b-biointerfaces,2014,117(9):75-81.
APA	He, Hongyan.,Xiao, Haihua.,Kuang, Huihui.,Xie,Zhigang.,Chen,Xuesi.,...&Huang,Yubin.(2014).Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery.colloids and surfaces b-biointerfaces,117(9),75-81.
MLA	He, Hongyan,et al."Synthesis of mesoporous silica nanoparticle-oxaliplatin conjugates for improved anticancer drug delivery".colloids and surfaces b-biointerfaces 117.9(2014):75-81.