Multifunctional Core-Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo

	Multifunctional Core-Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo
	Chen, Yin-Yin ; Ma, Ping-An ; Yang, Dong-Mei ; Wu,Yuan ; Dai,Yun-Lu ; Li,Chun-Xia ; Lin,Jun
刊名	chemistry-an asian journal
	2014
卷号	9 期号:2 页码:506-513
关键词	UP-CONVERSION NANOPARTICLES MESOPOROUS SILICA NANOPARTICLES CONTROLLED DRUG-DELIVERY UPCONVERTING NANOPARTICLES FLUORESCENT NANOPARTICLES OPTICAL SPECTROSCOPY PHOTODYNAMIC THERAPY NANOCRYSTALS NANOPROBES LUMINESCENCE
通讯作者	chen,yy
英文摘要	multifunctional, mesoporous, silica-coated upconversion luminescent/magnetic nagdf4:yb/er@nagdf4:yb@msio(2)peg (referred to as ucnps; peg=polyethylene glycol) nanocomposites were fabricated through a phase-transfer-assisted surfactant-templating coating process, followed by hydrophilic polymer (peg) functionalization to improve the stability and biocompatibility. the ucnp core imparts the nanomaterials with luminescence and magnetic properties for simultaneous upconversion optical and magnetic resonance (mr) imaging, whereas the mesoporous shell affords the nanomaterials the ability to load the anticancer drug doxorubicin. proof-of-principle in vitro and in vivo experiments are presented to demonstrate that the resultant composite nanomaterials can serve as nanotheranostics for synchronous upconversion luminescence/mr dual modal imaging and anticancer drug delivery; this finally realizes the integration of diagnostics and the treatment of cancers.
收录类别	SCI
语种	英语
WOS记录号	WOS:000331088600018
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/56238]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen, Yin-Yin,Ma, Ping-An,Yang, Dong-Mei,et al. Multifunctional Core-Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo[J]. chemistry-an asian journal,2014,9(2):506-513.
APA	Chen, Yin-Yin.,Ma, Ping-An.,Yang, Dong-Mei.,Wu,Yuan.,Dai,Yun-Lu.,...&Lin,Jun.(2014).Multifunctional Core-Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo.chemistry-an asian journal,9(2),506-513.
MLA	Chen, Yin-Yin,et al."Multifunctional Core-Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo".chemistry-an asian journal 9.2(2014):506-513.