Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin

	Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin
	Kuang,Huihui ; He,Hongyan ; Zhang,Zhiyun ; Qi,Yanxin ; Xie,Zhigang ; Jing,Xiabin ; Huang,Yubin
刊名	journal of materials chemistry b
	2014
卷号	2 期号:6 页码:659-667
关键词	DRUG-DELIVERY SYSTEMS INCLUSION COMPLEXATION AQUEOUS-SOLUTION COPOLYMER DEXTRAN ACID
通讯作者	huang,yb
英文摘要	injectable and biodegradable supramolecular hydrogels were prepared by nucleobase (adenine/thymine)terminated poly(ethylene oxide)s (a-peg-a/t-peg-t) and alpha-cyclodextrin (alpha-cd). the supramolecular hydrogels were thoroughly characterized by wxrd, rheometer, and sem. the gelation time depended on the molecular weight of peg and the concentration of polymer precursors. the rheological studies showed enhanced elastic modulus (g') of hydrogels, because of the hydrogen-bonding between a and t acting as additional network junctions. in vitro evaluation showed that the supramolecular hydrogels have acceptable biocompatibility, and are suitable for sustained and controlled release of loaded antitumor drugs. gel formation was also confirmed when the supramolecular hydrogels were subcutaneously injected into rats. in addition, in vivo experiments employing u14 cancer cell xenograft-bearing mice showed that the intratumoral injection of a dox-loaded a-peg-a/t-peg-t/alpha-cd gel inhibited tumor growth more effectively than that of free dox, dox-loaded peg/alpha-cd gel, saline or gel alone. hence, such a simple and convenient anti-cancer drug delivery system of a a-peg-a/t-peg-t/alpha-cd supramolecular hydrogel would be a promising candidate for many biomedical applications, especially in the area of the chemotherapy of solid tumors.
收录类别	SCI
语种	英语
WOS记录号	WOS:000329936400009
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/56214]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Kuang,Huihui,He,Hongyan,Zhang,Zhiyun,et al. Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin[J]. journal of materials chemistry b,2014,2(6):659-667.
APA	Kuang,Huihui.,He,Hongyan.,Zhang,Zhiyun.,Qi,Yanxin.,Xie,Zhigang.,...&Huang,Yubin.(2014).Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin.journal of materials chemistry b,2(6),659-667.
MLA	Kuang,Huihui,et al."Injectable and biodegradable supramolecular hydrogels formed by nucleobase-terminated poly(ethylene oxide)s and alpha-cyclodextrin".journal of materials chemistry b 2.6(2014):659-667.