Copper-Catalyzed Intramolecular C-C Bond Cleavage To Construct 2-Substituted Quinazolinones

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	Copper-Catalyzed Intramolecular C-C Bond Cleavage To Construct 2-Substituted Quinazolinones
	Hu, Ben-Quan 1,2; Wang, Li-Xia 1; Yang, Luo 2; Xiang, Jun-Feng 1; Tang, Ya-Lin 1
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2015-07-01
期号	20 页码:4504-4509
关键词	Synthetic methods Nitrogen heterocycles Cleavage reactions Copper Radicals
英文摘要	An efficient method for a copper-catalyzed intramolecular C-C bond cleavage to construct 2-substituted quinazolinones has been developed. The C-C bond at the 2-position of 2,2-disubstituted-1,2,3,4-tetrahydroquinazolinone was selectively cleaved by a Cu/air catalytic system. The trend for the cleavage was dependent on the leaving group in the order of: alkyl > methyl > phenyl > substituted aryl. The process described herein provides an explanation for the mechanism of the reaction between substituted 2-halobenzamides and a-substituted arylmethanamines to construct 2-substituted quinazolinones, which were previously reported and limited to the construction of 2-arylquinazolinones.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27872]
专题	化学研究所_分子动态与稳态结构实验室
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, BNLMS,Ctr Mol Sci, Beijing 100190, Peoples R China 2.Xiangtan Univ, Dept Chem, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Hu, Ben-Quan,Wang, Li-Xia,Yang, Luo,et al. Copper-Catalyzed Intramolecular C-C Bond Cleavage To Construct 2-Substituted Quinazolinones[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(20):4504-4509.
APA	Hu, Ben-Quan,Wang, Li-Xia,Yang, Luo,Xiang, Jun-Feng,&Tang, Ya-Lin.(2015).Copper-Catalyzed Intramolecular C-C Bond Cleavage To Construct 2-Substituted Quinazolinones.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(20),4504-4509.
MLA	Hu, Ben-Quan,et al."Copper-Catalyzed Intramolecular C-C Bond Cleavage To Construct 2-Substituted Quinazolinones".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .20(2015):4504-4509.