Crystal structure, nano-particle morphology and interaction with ATP of [NH3 CH2CH( NH2 ) CH3 ](2) [ M( VI ) O-2 (OC6H4O)(2) ] (M = MO0.6 W-0.4) and its activity to promote DNA cleavage

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Crystal structure, nano-particle morphology and interaction with ATP of [NH3 CH2CH( NH2 ) CH3 ](2) [ M( VI ) O-2 (OC6H4O)(2) ] (M = MO0.6 W-0.4) and its activity to promote DNA cleavage
	Lu Xiao-ming ; Pang Xiao-li ; Li Zhi-qiang ; Wang Ting ; Wang Zhen ; Ye Chao-hui
刊名	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
	2007-11-01
卷号	23 期号:6 页码:635-640
关键词	crystal structure nano-particle NMR ATP DNA cleavage activity
英文摘要	The title complex [NH3 CH2 CH( NH2 ) CH3 ](2) [ M( VI ) O-2 (OC6H4O)(2) ] (M = MO0.6 W-0.4) was synthesized via a simple solution-phase chemical route. The determination of single crystal X-ray diffxaction revealed that the title compound is crystallized in a monochnic system with P2 (1) /n space group, a = 1.0913 (10) nm, b = 1.0442 (10) nm, c = 1.8842 (19) nm, alpha 90 degrees, beta = 96.530 (17)degrees, gamma = 900, Z = 4, and V 2. 133 (4) nm(3). The mononuclear anionic unit [ M (VI) O-2 (OC6 H4O)(2)](2) - displays chiral pseudo-octahedral MO, I coordination geometry and is linked by chiral cations via hydrogen bond and pi center dot center dot center dot pi ir stacking interaction. The transmission electron microscopy images show that the title complex is comprised of nano-particles with diameters ranging from 20 to 50 run. The NMR study shows the H-1 downfield chemical shifts of [NH3CHaHbCH (NH2)CH3] (+) cations in the title complex when it is mixed with adenosine-triphosphate( ATP), and the chemical shift difference between Ha and Hb is increased greatly, and most of the catecholate ligands dissociate from the central metal atoms. The DNA cleavage activity experiment reveals that DNA cleavage promoted by the title complex is lower than that by Na2MoO4 which possesses antitumor property, but higher than that by Na2WO4.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	RESISTANT STAPHYLOCOCCUS-AUREUS ; TRANSITION-METAL COMPLEXES ; ANTITUMOR-ACTIVITY ; MEDICAL CHEMISTRY ; LIGAND ; TETRATHIOMOLYBDATE ; POLYOXOTUNGSTATES ; SEMIQUINONE ; CATECHOL ; TUNGSTEN
收录类别	SCI
语种	英语
WOS记录号	WOS:000251531400002
公开日期	2015-10-13
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/7938]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Lu Xiao-ming,Pang Xiao-li,Li Zhi-qiang,et al. Crystal structure, nano-particle morphology and interaction with ATP of [NH3 CH2CH( NH2 ) CH3 ](2) [ M( VI ) O-2 (OC6H4O)(2) ] (M = MO0.6 W-0.4) and its activity to promote DNA cleavage[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2007,23(6):635-640.
APA	Lu Xiao-ming,Pang Xiao-li,Li Zhi-qiang,Wang Ting,Wang Zhen,&Ye Chao-hui.(2007).Crystal structure, nano-particle morphology and interaction with ATP of [NH3 CH2CH( NH2 ) CH3 ](2) [ M( VI ) O-2 (OC6H4O)(2) ] (M = MO0.6 W-0.4) and its activity to promote DNA cleavage.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,23(6),635-640.
MLA	Lu Xiao-ming,et al."Crystal structure, nano-particle morphology and interaction with ATP of [NH3 CH2CH( NH2 ) CH3 ](2) [ M( VI ) O-2 (OC6H4O)(2) ] (M = MO0.6 W-0.4) and its activity to promote DNA cleavage".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 23.6(2007):635-640.