Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness

	Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness
	He, J. H.1; Cui, Y.2,3 ; Song, M.2,3 ; Yang, Y.1; Dang, Y. Y.1; Jiang, T. Z.2,3,4,5 ; Xu, R. X.1
刊名	ACTA NEUROLOGICA SCANDINAVICA
	2015-03-01
卷号	131 期号:3 页码:145-151
关键词	disorders of consciousness thalamus default mode network functional connectivity functional magnetic resonance imaging
英文摘要	Background - Interactions between the thalamus and the cortex play an important role in consciousness. The thalamus as a homogenous structure is less strongly connected with the default mode network (DMN) in patients with disorders of consciousness (DOC), but the roles of specific thalamic nuclei are not clear. The purpose of this study was to investigate the functional connectivity between individual thalamic nuclei and the DMN in DOC patients. Methods - Nine DOC patients and nine age-matched healthy controls were scanned with functional magnetic resonance imaging (fMRI) at resting state. Data-driven independent component analysis and hypothesis-driven region of interest-based correlation analysis were performed. Results - In comparison with healthy controls, DOC patients had significantly decreased functional connectivity between the mediodorsal thalamus and brain areas within the DMN, including the medial prefrontal cortex and posterior cingulate cortex/precuneus. Patients and controls did not show significant differences in functional connectivity in other thalamic nuclei. Conclusion - Our results suggest that functional connections between the mediodorsal thalamus and the DMN may play important roles in the pathogenesis of DOC.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Clinical Neurology
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	MONKEY RETROSPLENIAL CORTEX ; PREFRONTAL CORTEX ; BRAIN ; ORGANIZATION ; DISEASE ; LEVEL ; STATE
收录类别	SCI
语种	英语
WOS记录号	WOS:000351164300001
公开日期	2015-09-22
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/8088]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Beijing Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式 GB/T 7714	He, J. H.,Cui, Y.,Song, M.,et al. Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness[J]. ACTA NEUROLOGICA SCANDINAVICA,2015,131(3):145-151.
APA	He, J. H..,Cui, Y..,Song, M..,Yang, Y..,Dang, Y. Y..,...&Xu, R. X..(2015).Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness.ACTA NEUROLOGICA SCANDINAVICA,131(3),145-151.
MLA	He, J. H.,et al."Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness".ACTA NEUROLOGICA SCANDINAVICA 131.3(2015):145-151.