EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM

	EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM
	Wang, C.1; Liu, B.2,3 ; Long, H.2,3; Fan, L.2 ; Li, J.2 ; Zhang, X.2 ; Qiu, C.2 ; Yu, C.5; Jiang, T.1,2,3,4,6
刊名	NEUROSCIENCE
	2015-07-09
卷号	298 页码:380-388
关键词	brain-derived neurotrophic factor (BDNF) catechol-O-methyltransferase (COMT) dopamine frontostriatal system functional connectivity
英文摘要	The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	O-METHYLTRANSFERASE COMT ; ACTIVITY-DEPENDENT SECRETION ; ANTERIOR CINGULATE CORTEX ; FUNCTIONAL CONNECTIVITY ; NEUROTROPHIC FACTOR ; VAL66MET POLYMORPHISM ; NUCLEUS-ACCUMBENS ; BASAL GANGLIA ; PREFRONTAL CORTEX ; HUMAN BRAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000354783300029
公开日期	2015-09-22
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/7923]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China 5.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式 GB/T 7714	Wang, C.,Liu, B.,Long, H.,et al. EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM[J]. NEUROSCIENCE,2015,298:380-388.
APA	Wang, C..,Liu, B..,Long, H..,Fan, L..,Li, J..,...&Jiang, T..(2015).EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM.NEUROSCIENCE,298,380-388.
MLA	Wang, C.,et al."EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM".NEUROSCIENCE 298(2015):380-388.