Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理研究所回溯数据库(1956-2010)

	Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts
	Wang, Zhao-Xin 1; Zhang, John X.2; Wu, Qiu-Lin 1; Liu, Ning 3; Hu, Xiao-Ping 4,5; chan, Raymond C. K.6; Xiao, Zhuang-Wei 1
刊名	NEUROIMAGE
	2010
卷号	49 期号:1 页码:971-976
关键词	Addiction Heroin Affective processing Emotion Amygdala Visual cortex
ISSN号	1053-8119
通讯作者	Xiao, Zhuang-Wei
产权排序	6
英文摘要	Long-term exposure to drug may alter the neural system associated with affective processing, as evidenced by both clinical observations and behavioral data documenting dysfunctions in emotional experiences and processing in drug addicts. Although many imaging studies examined neural responses to drug or drug-related cues in addicts, there have been few studies explicitly designed to reveal their neural abnormalities in processing non-drug-related natural affective materials. The present study asked abstinent heroin addicts and normal controls to passively view standardized affective pictures of positive, negative, or neutral valence and compared their brain activities with functional MRI. Compared to normal controls, addicts showed reduced activation in right amygdala in response to the affective pictures, consistent with previous reports of blunted subjective experience for affective stimuli in addicts. Furthermore, in two visual cortical areas BA 19 and 37, while the controls showed greater responses to positive pictures than to negative ones replicating literature findings, the addicts showed the opposite pattern. The results reveal a complex pattern of altered processing of non-drug-related affected materials in addicts showing both heightened and blunted neural responses in different brain regions and for different stimulus valence. The present study highlights the importance of brain imaging research on drug addicts' processing of affective stimuli in understanding disruptions in their emotion circuitry. (C) 2009 Elsevier Inc. All rights reserved.
学科主题	生理心理学/生物心理学
收录类别	SCI
语种	英语
WOS记录号	WOS:000272031700097
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/13677]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China 2.Shantou Univ, Coll Med, Affiliated Hosp 1, Guangdong Key Lab Med Mol Imaging, Shantou, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming, Peoples R China 4.Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA 5.Emory Univ, Atlanta, GA 30322 USA 6.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhao-Xin,Zhang, John X.,Wu, Qiu-Lin,et al. Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts[J]. NEUROIMAGE,2010,49(1):971-976.
APA	Wang, Zhao-Xin.,Zhang, John X..,Wu, Qiu-Lin.,Liu, Ning.,Hu, Xiao-Ping.,...&Xiao, Zhuang-Wei.(2010).Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts.NEUROIMAGE,49(1),971-976.
MLA	Wang, Zhao-Xin,et al."Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts".NEUROIMAGE 49.1(2010):971-976.