Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis
	Qin, Zhan-Fen; Qin, Xiao-Fei; Yang, Lei; Han-Ting, Li; Zhao, Xing-Ru; Xu, Xiao-Bai
刊名	AQUATIC TOXICOLOGY
	2007-10-15
卷号	84 期号:3 页码:321-327
关键词	polychlorinated biphenyls secondary sexual development Xenopus laevis feminization/demasculinization
英文摘要	We have previously demonstrated that polychlorinated biphenyls (PCBs) have caused phenotypic feminization/demasculinization of gonadal development in Xenopus laevis. Whether PCBs affect secondary sexual development has remained unknown. In this study, X. laevis tadpoles were exposed to Aroclor 1254 and PCB3 from stage 46/47 (system of Nieuwkoop and Faber) for up to I month postmetamorphosis. After 24 months postmetamorphosis, the degree of secondary sexual development was examined. Male oviducts were observed in some of the PCB-exposed male frogs, but not in control males. These male oviducts had not completely developed in histological structure when compared with mature female oviducts. Larynx weight and width of PCB-exposed males were significantly less than those of control males. Laryngeal histology showed that PCBs inhibited cartilaginous and muscular development of male frogs, i.e. elastic cartilages had not completely developed and laryngeal muscle fibers were smaller. In a further study on adult male frogs, a decrease in serum testosterone level was found in PCB-exposed frogs compared with controls, but serum estradiol level was not significantly affected. Our study suggests that PCBs can cause phenotypic feminization/demasculinization of male genital ducts and larynges, and these effects may, in part, result from the decrease in serum testosterone level in X. laevis. (C) 2007 Elsevier B.V. All rights reserved.
WOS记录号	WOS:000249569400003
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/22463]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Qin, Zhan-Fen,Qin, Xiao-Fei,Yang, Lei,et al. Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis[J]. AQUATIC TOXICOLOGY,2007,84(3):321-327.
APA	Qin, Zhan-Fen,Qin, Xiao-Fei,Yang, Lei,Han-Ting, Li,Zhao, Xing-Ru,&Xu, Xiao-Bai.(2007).Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis.AQUATIC TOXICOLOGY,84(3),321-327.
MLA	Qin, Zhan-Fen,et al."Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis".AQUATIC TOXICOLOGY 84.3(2007):321-327.