MRI-visible liposome nanovehicles for potential tumor-targeted delivery of multimodal therapies

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	MRI-visible liposome nanovehicles for potential tumor-targeted delivery of multimodal therapies
	Ren, Lili; Chen, Shizhen; Li, Haidong; Zhang, Zhiying; Ye, Chaohui; Liu, Maili; Zhou, Xin
刊名	NANOSCALE
	2015
卷号	7 期号:30 页码:12843-12850
英文摘要	Real-time diagnosis and monitoring of disease development, and therapeutic responses to treatment, are possible by theranostic magnetic resonance imaging (MRI). Here we report the synthesis of a multifunctional liposome, which contains Gd-DOTA (an MRI probe), paclitaxel and c(RGDyk) (a targeted peptide). This nanoparticle overcame the insolubility of paclitaxel, reduced the side effects of FDA-approved formulation of PTX-Cre (Taxol (R)) and improved drug delivery efficiency to the tumor.c(RGDyk) modification greatly enhanced the cytotoxicity of the drug in tumor cells A549. The T-1 relaxivity in tumor cells treated with the targeted liposome formulation was increased 16-fold when compared with the non-targeted group. In vivo, the tumors in mice were visualized using T-1-weighted imaging after administration of the liposome. Also the tumor growth could be inhibited well after the treatment. Fluorescence images in vitro and ex vivo also showed the targeting effect of this liposome in tumor cells, indicating that this nanovehicle could limit the off-target side effects of anticancer drugs and contrast agents. These findings lay the foundation for further tumor inhibition study and application of this delivery vehicle in cancer therapy settings.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	DRUG-DELIVERY ; IN-VIVO ; ANTITUMOR-ACTIVITY ; CANCER ; PACLITAXEL ; NANOPARTICLES ; MICROENVIRONMENT ; NANOMEDICINE ; ANGIOGENESIS ; NANOCARRIERS
收录类别	SCI
语种	英语
WOS记录号	WOS:000358615200010
公开日期	2015-09-15
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/7830]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Ren, Lili,Chen, Shizhen,Li, Haidong,et al. MRI-visible liposome nanovehicles for potential tumor-targeted delivery of multimodal therapies[J]. NANOSCALE,2015,7(30):12843-12850.
APA	Ren, Lili.,Chen, Shizhen.,Li, Haidong.,Zhang, Zhiying.,Ye, Chaohui.,...&Zhou, Xin.(2015).MRI-visible liposome nanovehicles for potential tumor-targeted delivery of multimodal therapies.NANOSCALE,7(30),12843-12850.
MLA	Ren, Lili,et al."MRI-visible liposome nanovehicles for potential tumor-targeted delivery of multimodal therapies".NANOSCALE 7.30(2015):12843-12850.