The hypoxia signaling pathway and hypoxic adaptation in fishes

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物分子与细胞生物学研究中心 > 期刊论文

	The hypoxia signaling pathway and hypoxic adaptation in fishes
	Xiao Wuhan
刊名	SCIENCE CHINA-LIFE SCIENCES
	2015-02-01
卷号	58 期号:2 页码:148-155
关键词	hypoxia hypoxia-inducible factors PHDs pVHL FIH fish
ISSN号	1674-7305
通讯作者	Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China.
英文摘要	The hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway present in animals ranging from Caenorhabditis elegans to mammals. The pathway is crucial for oxygen homeostasis maintenance. Hypoxia-inducible factors (HIF-1 alpha and HIF-2 alpha) are master regulators in the hypoxia signaling pathway. Oxygen concentrations vary a lot in the aquatic environment. To deal with this, fishes have adapted and developed varying strategies for living in hypoxic conditions. Investigations into the strategies and mechanisms of hypoxia adaptation in fishes will allow us to understand fish speciation and breed hypoxia-tolerant fish species/strains. This review summarizes the process of the hypoxia signaling pathway and its regulation, as well as the mechanism of hypoxia adaptation in fishes.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biology
研究领域[WOS]	Life Sciences & Biomedicine - Other Topics
关键词[WOS]	GOLDFISH CARASSIUS-AURATUS ; BASS DICENTRARCHUS-LABRAX ; FACTOR-ALPHA SUBUNITS ; INDUCIBLE-FACTOR ; GENE-EXPRESSION ; CRUCIAN CARP ; FACTOR HIF-1-ALPHA ; OXIDATIVE STRESS ; HIF-ALPHA ; TRANSCRIPTIONAL REGULATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000349407000004
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/23989]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
作者单位	Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Xiao Wuhan. The hypoxia signaling pathway and hypoxic adaptation in fishes[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(2):148-155.
APA	Xiao Wuhan.(2015).The hypoxia signaling pathway and hypoxic adaptation in fishes.SCIENCE CHINA-LIFE SCIENCES,58(2),148-155.
MLA	Xiao Wuhan."The hypoxia signaling pathway and hypoxic adaptation in fishes".SCIENCE CHINA-LIFE SCIENCES 58.2(2015):148-155.