Finite element simulation of stress relaxation process in living cells

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	Finite element simulation of stress relaxation process in living cells
	Wei FN(魏发南); Zhou PL(周培林); Li GY(李广勇); Liu LQ(刘连庆)
	2015
会议名称	10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
会议日期	April 7, 2015 - April 11, 2015
会议地点	Xi'an, China
关键词	Cell mechanics Finite element simulation Viscoelastic
页码	67-71
中文摘要	In this manuscript, we investigated the fundamental mechanism of stress relaxation phenomenon by employing finite element simulation. Through finite element simulations, the evolution of stress distribution, deformation field and the interaction force was wholly recorded during both the loading and stress relaxation stages. With the developed simulation model, the sensitivity of force-time curves on cell height and substrate stiffness was thoroughly studied by changing the thickness of cell and Young's modulus of the substrate. The simulation results indicated that the variation of cell height leads to the significant change of F-t curve's magnitude but tiny deviation of the curve's shape. And the influence originates from the substrate can be totally eliminated with relatively hard substrate. Finally, using the viscoelastic parameters extracted from actual stress relaxation experiment, the dynamic mechanical behavior of L929 cells is simulated and investigated. A comparison between the experimental and simulation F-t curves demonstrated the effectiveness of the proposed finite element simulation approach.
收录类别	EI ; CPCI（ISTP）
产权排序	1
会议主办者	Institute of Electrical and Electronics Engineers Inc.
会议录	2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
会议录出版者	IEEE
会议录出版地	Piscataway, NJ, USA
语种	英语
ISBN号	978-1-4673-6695-3
WOS记录号	WOS:000380505700017
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/16899]
专题	沈阳自动化研究所_机器人学研究室
推荐引用方式 GB/T 7714	Wei FN,Zhou PL,Li GY,et al. Finite element simulation of stress relaxation process in living cells[C]. 见:10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015. Xi'an, China. April 7, 2015 - April 11, 2015.