Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery

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	Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery
	Wang, Lianyan; Yang, Tingyuan; Ma, Guanghui
刊名	CURRENT PHARMACEUTICAL DESIGN
	2015
卷号	21 期号:19 页码:2563-2598
关键词	Membrane emulsification protein/peptide drugs microparticle adjuvant bioactivity
ISSN号	1381-6128
英文摘要	Biodegradable particles have important applications in Drug Delivery Systems (DDS) of protein/peptide drugs. And recently, particle systems have also showed to be powerful for vaccine delivery (adjuvant) in order to solve the difficulties when conventional Alum adjuvant was used. However, in above applications, the problems of broad size distribution and poor reproducibility of particles, and deactivation of protein during the preparation, storage and release, are still big challenges. Furthermore, particle should be designed specially according to antigen type and purpose in vaccine delivery. In this article, the techniques to control the diameter of microparticle (MP) will be introduced at the first, and then the strategies about how to maintain the bioactivity of protein drugs during preparation and drug release will be reviewed. Furthermore, particle application specially designed for vaccine delivery to enhance both humoral response and cellular response, will be described.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	SIZED CHITOSAN MICROSPHERES ; SOLVENT EVAPORATION METHOD ; MEDIATED IMMUNE-RESPONSES ; DOUBLE EMULSION TECHNIQUE ; LOADED PLGA MICROSPHERES ; ORAL DELIVERY ; IN-VITRO ; CONTROLLED-RELEASE ; PLA MICROCAPSULES ; DENDRITIC CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000354609400004
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/19249]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lianyan,Yang, Tingyuan,Ma, Guanghui. Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery[J]. CURRENT PHARMACEUTICAL DESIGN,2015,21(19):2563-2598.
APA	Wang, Lianyan,Yang, Tingyuan,&Ma, Guanghui.(2015).Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery.CURRENT PHARMACEUTICAL DESIGN,21(19),2563-2598.
MLA	Wang, Lianyan,et al."Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery".CURRENT PHARMACEUTICAL DESIGN 21.19(2015):2563-2598.